Effect of Modified Polyhemoglobin on the Oxidative Damage After Ischemia-Reperfusion in the Liver
- Author(s)
- K.C. Mun; J.H. Bae; S.I. Suh; Y.H. Kim; S.H. Lee; S.P. Kim; T.K. Kwon; J.S. Hwang
- Keimyung Author(s)
- Bae, Jae Hoon; Mun, Kyo Cheol; Kim, You Hee; Suh, Seong Il; Kim, Sang Pyo; Kwon, Taeg Kyu; Hwang, Jae Seok
- Department
- Dept. of Physiology (생리학)
Dept. of Biochemistry (생화학)
Dept. of Microbiology (미생물학)
Dept. of Pathology (병리학)
Dept. of Immunology (면역학)
Dept. of Internal Medicine (내과학)
Institute for Medical Science (의과학연구소)
- Journal Title
- Transplantation Proceedings
- Issued Date
- 2003
- Volume
- 35
- Issue
- 1
- Abstract
- LIVER SUFFERS ischemia-reperfusion injury during
transplantation.1–3 Reactive oxygen species generated
by xanthine oxidase during reperfusion of the ischemic liver
might be in part responsible for the hepatic injury.4–6
Antioxidant enzymes, such as superoxide dismutase (SOD),
catalase, and glutathione peroxidase, remove oxygen free
radicals.7 Using glutaraldehyde we made cross-linked hemoglobin,
containing SOD and catalase, to protect against
ischemia-reperfusion injury during transplantation.
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