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Prognostic Significance of Simvastatin Therapy in Patients With Ischemic Heart Failure Who Underwent Percutaneous Coronary Intervention for Acute Myocardial Infarction

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Author(s)
Young Joon HongMyung Ho JeongDae Woo HyunSeung Ho HurKwon Bae KimWeon KimSang Yup LimSang Hyun LeeSeo Na HongDong Goo KangKyung Ho YunKye Hun KimYun Sang LeeHyung Wook ParkJu Han KimYoung Keun AhnJeong Gwan ChoJong Chun ParkJung Chaee Kang
Keimyung Author(s)
Hur, Seung HoKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Journal of Cardiology
Issued Date
2005
Volume
95
Issue
5
Abstract
We prospectively followed 202 patients with ischemic heart failure who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (left ventricular [LV] ejection fraction <40%). Patients were divided into 2 groups: groups I (simvastatin group, n106, aged 60.8 10.3 years, men 71.7%) and II (non-simvastatin group, n 96, aged 60.9 10.4 years, men 78.1%). During 1-year clinical follow-up, simvastatin therapy was associated with a significant reduction in mortality (1.9% vs 7.5%, p 0.048), restenosis rate (25.7% vs 43.1%, p 0.033), and repeat PCI rate (25.7% vs 43.1%, p 0.033), and with significant improvement in LV ejection fraction (31% to 42% vs 32% to 39%, p 0.042). The event-free survival rate was higher in group I than in group II (79.8% vs 57.0%, p 0.001). In conclusion, simvastatin therapy improves LV systolic function and decreases mortality, restenosis, and repeat PCI rate in patients with ischemic heart failure who underwent PCI for acute myocardial infarction. 2005 by Excerpta Medica Inc.
Keimyung Author(s)(Kor)
허승호
김권배
Publisher
School of Medicine
Citation
Young Joon Hong et al. (2005). Prognostic Significance of Simvastatin Therapy in
Patients With Ischemic Heart Failure Who Underwent
Percutaneous Coronary Intervention for Acute
Myocardial Infarction. American Journal of Cardiology, 95(5), 619–622. doi: 10.1016/j.amjcard.2004.10.039
Type
Article
ISSN
0002-9149
Source
https://linkinghub.elsevier.com/retrieve/pii/S0002914904017825
DOI
10.1016/j.amjcard.2004.10.039
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34462
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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