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Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN- γ (Mig) and Chemokine Responsive to γ-2 (Crg-2)1

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Author(s)
Jong-Wook ParkM. Eilene GruysKathy McCormickJong-Keuk LeeJeffrey SubleskiJon M. WiggintonRobert G. FentonJi-Ming WangRobert H. Wiltrout
Keimyung Author(s)
Park, Jong Wook
Department
Dept. of Immunology (면역학)
Journal Title
journal of immunology
Issued Date
2001
Volume
166
Issue
6
Abstract
The IFN-g-inducible proteins monokine induced by IFN-g (Mig) and chemokine responsive to g-2 (Crg-2) can contribute to
IL-12-induced antiangiogenic and leukocyte-recruiting activities, but the extent to which leukocytes vs parenchymal cells in
different organs contribute to the production of these molecules remains unclear. The results presented herein show that IFNg-
dependent induction of Mig and Crg-2 gene expression can occur in many nonlymphoid organs, and these genes are rapidly
induced in purified hepatocytes isolated from mice treated with IL-2 plus IL-12, or from Hepa 1-6 hepatoma cells treated in vitro
with IFN-g. In addition to depending on IFN-g, the ability of IL-12 or IL-2/IL-12 to induce Mig and Crg-2 gene expression in
purified hepatocytes also is accompanied by the coordinate up-regulation of the IFN-g R a and b-chains, in the absence of IL-12R
components. Supernatants of primary hepatocytes obtained from mice treated in vivo with IL-2/IL-12 or from hepatocytes treated
in vitro with IFN-g contain increased chemotactic activity for enriched human and mouse CD31 T cells, as well as mouse DX51
NK cells. The hepatocyte-derived chemotactic activity for mouse T cells but not NK cells was ablated by Abs specific for Mig and
Crg-2. These results suggest that parenchymal cells in some organs may contribute substantially to initiation and/or amplification
of inflammatory or antitumor responses.
Keimyung Author(s)(Kor)
박종욱
Publisher
School of Medicine
Citation
Jong-Wook Park et al. (2001). Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN- γ (Mig) and Chemokine Responsive to γ-2 (Crg-2)1. journal of immunology, 166(6), 3763–3770. doi: 10.4049/jimmunol.166.6.3763
Type
Article
ISSN
0022-1767
DOI
10.4049/jimmunol.166.6.3763
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34478
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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