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Characterization and bacterial anti-adherent effect on modified PMMA denture acrylic resin containing platinum nanoparticles

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Author(s)
Ki-Young Nam
Keimyung Author(s)
Nam, Ki Young
Department
Dept. of Dentistry (치과학)
Journal Title
Journal of Advanced Prosthodontics
Issued Date
2014
Volume
6
Issue
3
Keyword
Platinum nanoparticlesDenture acrylic resinNanocompositeAnti-adherent effect
Abstract
PURPOSE. This study characterized the synthesis of a modified PMMA (Polymethyl methacrylate) denture acrylic
loading platinum nanoparticles (PtN) and assessed its bacterial inhibitory efficacy to produce novel antimicrobial
denture base material. MATERIALS AND METHODS. Polymerized PMMA denture acrylic disc (20 mm x 2 mm)
specimens containing 0 (control), 10, 50, 100 and 200 mg/L of PtN were fabricated respectively. The obtained
platinum-PMMA nanocomposite (PtNC) was characterized by TEM (transmission electron microscopy), SEM/EDX
(scanning electron microscope/energy dispersive X-ray spectroscopy), thermogravimetric and atomic absorption
spectrophotometer analysis. In antimicrobial assay, specimens were placed on the cell culture plate, and 100 µL
of microbial suspensions of S. mutans (Streptococcus mutans) and S. sobrinus (Streptococcus sobrinus) were
inoculated then incubated at 37oC for 24 hours. The bacterial attachment was tested by FACS (fluorescenceactivated
cell sorting) analysis after staining with fluorescent probe. RESULTS. PtN were successfully loaded and
uniformly immobilized into PMMA denture acrylic with a proper thermal stability and similar surface
morphology as compared to control. PtNC expressed significant bacterial anti-adherent effect rather than
bactericidal effect above 50 mg/L PtN loaded when compared to pristine PMMA (P=.01) with no or extremely
small amounts of Pt ion eluted. CONCLUSION. This is the first report on the synthesis and its antibacterial
activity of Pt-PMMA nanocomposite. PMMA denture acrylic loading PtN could be a possible intrinsic
antimicrobial denture material with proper mechanical characteristics, meeting those specified for denture bases.
For clinical application, future studies including biocompatibility, color stability and warranting the long-term
effect were still required. [ J Adv Prosthodont 2014;6:207-14]
KEY WORDS: Platinum nanoparticles; Denture acrylic resin; Nanocomposite; Anti-adherent effect
Keimyung Author(s)(Kor)
남기영
Publisher
School of Medicine
Citation
Ki-Young Nam. (2014). Characterization and bacterial anti-adherent effect on modified PMMA denture acrylic resin containing platinum nanoparticles. Journal of Advanced Prosthodontics, 6(3), 207–214. doi: 10.4047/jap.2014.6.3.207
Type
Article
ISSN
2005-7806
DOI
10.4047/jap.2014.6.3.207
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34481
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Dentistry (치과학)
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