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Effects of Extrahepatic Cholestasis on Hepatic a-D-Mannosidase Activity in Chronic Ethanol Intoxicated Rats

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Author(s)
Si-Woo BaeChun-Sik KwakChong-Guk Yoon
Alternative Author(s)
Kwak, Chun Sik
Department
Dept. of Biochemistry (생화학)
Journal Title
Korean Journal of Biomedical Laboratory Sciences
Issued Date
2003
Volume
9
Number
1
Keyword
Common bile duct ligationEthanol intoxicationExtrahepatic cholestasisa-D-Mannosidase
Abstract
Hepatic subcellular a-D-mannosidases activities and its Km and Vmax values were determined in chronic ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. In case of extrahepatic cholestasis, chronic ethanol intoxication in animals led to the increased activities of liver Golgi and microsomal a-D-mannosidase as well as the Vmax values of these enzymes. However, the difference of Km values on hepatic subcellular enzymes were not found between the experimental groups. Therefore, the results indicate that the liver Golgi and microsomal a-D-mannosidase may be more induced in chronic ethanol intoxication animals in case of cholestasis. Accordingly, the resulting data supported the fact that alcoholic drinks may led to enhancement of the hepatobiliary liver damage. Key Words: Common bile duct ligation, Ethanol intoxication, Extrahepatic cholestasis, a-D-Mannosidase
Affiliated Author(s)
곽춘식
Publisher
School of Medicine
Citation
Si-Woo Bae et al. (2003). Effects of Extrahepatic Cholestasis on Hepatic a-D-Mannosidase Activity in Chronic
Ethanol Intoxicated Rats. Korean Journal of Biomedical Laboratory Sciences, 9(1), 21–27.
Type
Article
ISSN
1226-0487
Fulltext
http://www.dbpia.co.kr/Journal/ArticleDetail/NODE00761293
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34490
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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