Effects of Extrahepatic Cholestasis on Hepatic a-D-Mannosidase Activity in Chronic
Ethanol Intoxicated Rats
- Author(s)
- Si-Woo Bae; Chun-Sik Kwak; Chong-Guk Yoon
- Alternative Author(s)
- Kwak, Chun Sik
- Department
- Dept. of Biochemistry (생화학)
- Journal Title
- Korean Journal of Biomedical Laboratory Sciences
- Issued Date
- 2003
- Volume
- 9
- Number
- 1
- Keyword
- Common bile duct ligation; Ethanol intoxication; Extrahepatic cholestasis; a-D-Mannosidase
- Abstract
- Hepatic subcellular a-D-mannosidases activities and its Km and Vmax values were determined in chronic ethanol intoxicated rats with extrahepatic cholestasis induced by common bile duct ligation to manifest the biochemical background of alcohol drinking hazard under the hepatobiliary disease. In case of extrahepatic cholestasis, chronic ethanol intoxication in animals led to the increased activities of liver Golgi and microsomal a-D-mannosidase as well as the Vmax values of these enzymes. However, the difference of Km values on hepatic subcellular enzymes were not found between the experimental groups. Therefore, the results indicate that the liver Golgi and microsomal a-D-mannosidase may be more induced in chronic ethanol intoxication animals in case of cholestasis. Accordingly, the resulting data supported the fact that alcoholic drinks may led to enhancement of the hepatobiliary liver damage. Key Words: Common bile duct ligation, Ethanol intoxication, Extrahepatic cholestasis, a-D-Mannosidase
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