계명대학교 의학도서관 Repository

Magnesium Sulphate Attenuates Tourniquet-induced Hypertension and Spinal c-fos mRNA Expression: a Comparison with Ketamine

Metadata Downloads
Author(s)
DH LEEDL JEESY KIMJM KIMHM LEE
Keimyung Author(s)
Kim, Jin Mo
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Journal of International Medical Research
Issued Date
2006
Volume
34
Issue
6
Keyword
KETAMINEMAGNESIUM SULPHATEHYPERTENSIONTOURNIQUETC-FOS MRNA EXPRESSION
Abstract
Magnesium and ketamine are wellknown
N-methyl-D-aspartic acid receptor
antagonists. The aim of this study was
to determine whether magnesium, in
comparison with ketamine, attenuates
tourniquet-induced hypertension and
spinal c-fos mRNA expression. Rats were
divided into four treatment groups: normal
(baseline for c-fos mRNA expression);
control (saline injection); magnesium
injection; and ketamine injection. Arterial
blood pressure and c-fos mRNA expression
at 60 min were higher in the control than
in the magnesium and ketamine groups.
Human patients under sevoflurane–
oxygen/nitrous oxide anaesthesia were
also assigned to receive similar treatments.
In humans, arterial blood pressure was
increased in the control group at 50 min
and thereafter compared with the
magnesium and ketamine groups; the
magnesium and ketamine groups did
not differ. Magnesium and ketamine
are equally effective in attenuating
tourniquet-induced hypertension and
spinal c-fos mRNA expression, suggesting
that this effect may be due to reduced
pain transmission.
KEY WORDS: KETAMINE; MAGNESIUM SULPHATE; HYPERTENSION; TOURNIQUET;
C-FOS MRNA EXPRESSION
Keimyung Author(s)(Kor)
김진모
Publisher
School of Medicine
Citation
DH LEE et al. (2006). Magnesium Sulphate Attenuates
Tourniquet-induced Hypertension
and Spinal c-fos mRNA Expression:
a Comparison with Ketamine. Journal of International Medical Research, 34(6), 573–584. doi: 10.1177/147323000603400602
Type
Article
ISSN
0300-0605
Source
http://journals.sagepub.com.proxy.dsmc.or.kr/doi/abs/10.1177/147323000603400602?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1177/147323000603400602
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34499
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.