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Resveratrol에 의한 암 전이 관련 유전자 MMP-9의 발현 조절

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Author(s)
우주형김영호백원기서성일서민호박종욱권택규
Keimyung Author(s)
Park, Jong WookKwon, Taeg KyuBaek, Won KiSuh, Seong IlSuh, Min Ho
Department
Dept. of Immunology (면역학)
Dept. of Microbiology (미생물학)
Journal Title
Journal of Bacteriology and Virology
Issued Date
2003
Volume
33
Issue
3
Keyword
ResveratrolMMP-9JNKAPIPMA
Abstract
Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with the expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways including those activated by phorbol myristate acetate (PMA). We found that resveratrol, a phytoalexin present in grapes, significantly inhibits the PMA-induced increase of MMP-9 expression and activity. These effects of resveratrol were dose-dependent and correlated with the suppression of MMP-9 mRNA expression levels. PMA caused a 23-fold increase in MMP-9 promoter activity, which was suppressed by resveratrol. Transient transfection by MMP-9 constructs, in which specific transcriptional factors were mutagenized, indicated that the effects of PMA and resveratrol were mediated via API and NFkB response elements. Resveratrol inhibited PMA-mediated activation of c-Jun N-terminal kinase (JNK) and protein kinase C (PKC)-5 activation. Therefore, we conclude that the inhibitory activities of resveratrol on MMP-9, JNK, and PKC-5 may have therapeutic potential for controlling growth and invasiveness of tumors.

Key Words: Resveratrol, MMP-9, JNK, API,PMA
Alternative Title
Expressional Regulation of Cancer Metastasis Related Gene, MMP-9, by Resveratrol
Keimyung Author(s)(Kor)
박종욱
권택규
백원기
서성일
서민호
Publisher
School of Medicine
Citation
우주형 et al. (2003). Resveratrol에 의한 암 전이 관련 유전자 MMP-9의 발현 조절. Journal of Bacteriology and Virology, 33(3), 235–243.
Type
Article
ISSN
1598-2467
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34502
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Microbiology (미생물학)
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