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Combination of Uric Acid and NT-ProBNP: A More Useful Prognostic Marker for Short-Term Clinical Outcomes in Patients with Acute Heart Failure

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Author(s)
Hyoung-Seob ParkHyungseop KimJi-Hyun SohnHong-Won ShinYun-Kyeong ChoHyuck-Jun YoonChang-Wook NamSeung-Ho HurYoon-Nyun KimKwon-Bae KimHee-Joon Park
Keimyung Author(s)
Park, Hyoung SeobKim, Hyung SeopCho, Yun KyeongYoon, Hyuck JunNam, Chang WookHur, Seung HoKim, Yoon NyunKim, Kwon BaePark, Hee Jun
Department
Dept. of Internal Medicine (내과학)
Dept. of Biomedical Engineering (의용공학과)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2010
Volume
25
Issue
3
Keyword
Uric acidNatriuretic peptidesHeart failure
Abstract
Background/Aims: In patients with heart failure (HF), N-terminal prohormone brain natriuretic peptide (NT-ProBNP) is a standard prognostic indicator. In addition, uric acid (UA) was recently established as a prognostic marker for poor outcome in chronic HF. The aim of this study was to determine the combined role of UA and NT-ProBNP as prognostic markers for short-term outcomes of acute heart failure (AHF).

Methods: The levels of UA and NT-ProBNP were determined in 193 patients (age, 69 土 13 years; 76 males) admitted with AHF. Patients were followed for 3 months and evaluated for cardiovascular events, defined as cardiac death and/or readmission for HF.

Results: Of the 193 patients, 23 (11.9%) died and 20 (10.4%) were readmitted for HF during the 3-month follow-up period. Based on univariate analysis, possible predictors of short-term cardiovascular events were high levels of UA and NT-ProBNP, low creatinine clearance, no angiotensin converting enzyme inhibitors or angiotensin receptor blockers, and old age. Multivariate Cox hazard analysis showed that UA levels were independently associated with increased incidence of cardiovascular events (hazard ratio, 1.115; 95% confidence interval, 1.006 to 1.235; p = 0.037). Kaplan-Meier survival analysis revealed that patients with UA levels > 8.0 mg/dL and NT-ProBNP levels > 4,210 pg/mL were at highest risk for cardiac events (p = 0.01).

Conclusions: The combination of UA and NT-ProBNP levels appears to be more useful than either marker alone as an independent predictor for short-term outcomes in patients with AHF. (Korean J Intern Med 2010; 25:253-259)
Keywords: Uric acid; Natriuretic peptides; Heart failure
Keimyung Author(s)(Kor)
박형섭
김형섭
조윤경
윤혁준
남창욱
허승호
김윤년
김권배
박희준
Publisher
School of Medicine
Citation
Hyoung-Seob Park et al. (2010). Combination of Uric Acid and NT-ProBNP: A More Useful Prognostic Marker for Short-Term Clinical Outcomes in Patients with Acute Heart Failure. Korean Journal of Internal Medicine, 25(3), 253–259. doi: 10.3904/kjim.2010.25.3.253
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2010.25.3.253
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34567
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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