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Comparison of Sirolimus and Paclitaxel-Eluting Stents for Complex Coronary Lesions: An Intravascular Ultrasound Study

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Author(s)
Yun-Kyeong ChoSeung-Ho HurHyun-Tae KimIn-Cheol KimHyoung-Seob ParkHyuck-Jun YoonChang-Wook NamHyungseop KimSeong-Wook HanYoon-Nyun KimKwon-Bae Kim
Keimyung Author(s)
Cho, Yun KyeongHur, Seung HoKim, In CheolPark, Hyoung SeobYoon, Hyuck JunNam, Chang WookKim, Hyung SeopHan, Seong WookKim, Yoon NyunKim, Kwon Bae
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2009
Volume
24
Issue
4
Keyword
Coronary artery diseaseDrug-eluting stentsUltrasonography
Abstract
Background/Aims

Recent intravascular ultrasound (IVUS) studies of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have demonstrated a significant reduction in neointimal hyperplasia (NIH) based on simple coronary lesions. In this study, we evaluated the efficacy of SES and PES using IVUS in complex coronary lesions.


Methods

Eighty-seven patients in whom 95 drug-eluting stents (66 SES and 29 PES) were implanted in complex coronary lesions were enrolled in this study. Case selection was based on the availability of IVUS and quantitative coronary angiographic (QCA) examinations at the index procedure and at follow-up. The neointimal volume index (volume/length: NIVI) and percent neointimal volume (% NIV) were calculated. The longitudinal length of stented segments without IVUS-detectable NIH was also evaluated.


Results

The baseline patient demographics were similar between the SES and PES groups. At follow-up, no significant differences were observed in the vessel, plaque, or stent volume indices between the two groups. However, the NIVI and % NIV were significantly lower in the SES group (p<0.01). The longitudinal length of stented segments without IVUS-detectable NIH was significantly higher in the SES group (p<0.01). The net gain was significantly larger in the SES group (2.3±0.7 vs. 2.0×0.6 mm, p=0.025), while the rate of major adverse cardiac events was similar between the two groups.


Conclusions

Although SES showed significantly greater suppression of NIH at follow-up, both stents were highly effective at inhibiting NIH in complex coronary lesions.

Keywords: Coronary artery disease, Drug-eluting stents, Ultrasonography
Keimyung Author(s)(Kor)
조윤경
허승호
김인철
박형섭
윤혁준
남창욱
김형섭
한성욱
김윤년
김권배
Publisher
School of Medicine
Citation
Yun-Kyeong Cho et al. (2009). Comparison of Sirolimus and Paclitaxel-Eluting Stents for Complex Coronary Lesions: An Intravascular Ultrasound Study. Korean Journal of Internal Medicine, 24(4), 323–329. doi: 10.3904/kjim.2009.24.4.323
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2009.24.4.323
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34569
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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