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Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer

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Author(s)
Hong Suk SongIn Ho KimSoo Sang SohnKun Young KwonWon Sik Lee
Keimyung Author(s)
Kwon, Kun YoungKim, In HoSohn, Soo SangSong, Hong Suk
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Dept. of Internal Medicine (내과학)
Journal Title
Korean Journal of Internal Medicine
Issued Date
2005
Volume
20
Issue
1
Keyword
Gastric cancerPrognosisp53Rb geneImmunohistochemistry
Abstract
Background

The aim of this study was to determine the prognostic significance of the expression of p53 and retinoblastoma (Rb) gene products in cases of curatively resected gastric adenocarcinoma, by immunohistochemical analysis.


Methods

Between January 1996 and December 2001, 736 curatively resected gastric cancer patients underwent immunohistochemical staining for p53 or Rb proteins (pRb), and we retrospectively analyzed the correlation of our results with the clinical outcomes of these cases.


Results

High levels of expression of p53 (>25% p53-positive cells) and Rb (>50% Rb-positive cells) proteins were detected in 40.1% and 43.7% of cases, respectively. Tubular type was found to frequently exhibit higher levels of p53 expression (high expression in 44.2%) than signet ring cell type (high expression in 26.0%) (p=0.042). The incidence of vascular invasion was lower in the high pRb expressors (43.2%) than in the pRb low expressors (56.8%), but this was not a statistically significant discrepancy (p=0.063). Preoperative CEA levels were found to be low in high pRb expressors: initial CEA level in the high pRb expressors was 2.31±3.30 ng/mL, and was 5.18±24.80 ng/mL in the low pRb expressors (p=0.033). Tumor depth and node metastasis were both independent of the levels of expression of p53 and Rb proteins. The seven-year overall survival rate and relapse-free survival rates of patients were 87.2% and 75.7%, respectively. Multivariate Cox regression analysis indicated that tumor stage, tumor size, patient age and pRb expression were the significant prognostic factors with regard to overall survival, and tumor stage and age were both significant factors with regard to relapse-free survival.


Conclusion

Immunohistochemical staining of retinoblastoma gene products was an independent prognostic factor for the prediction of overall survival in curatively resected gastric cancer patients.

Keywords: Gastric cancer, Prognosis, p53, Rb gene, Immunohistochemistry
Keimyung Author(s)(Kor)
권건영
김인호
손수상
송홍석
Publisher
School of Medicine
Citation
Hong Suk Song et al. (2005). Prognostic Significance of Immunohistochemical Expression of p53 and Retinoblastoma Gene Protein (pRB) in Curatively Resected Gastric Cancer. Korean Journal of Internal Medicine, 20(1), 1–7. doi: 10.3904/kjim.2005.20.1.1
Type
Article
ISSN
1226-3303
DOI
10.3904/kjim.2005.20.1.1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34577
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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