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Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group

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Author(s)
Hyojin KimHyo Sup ShimLucia KimTae-Jung KimKun Young KwonGeon Kook LeeJin-Haeng ChungKorean Cardiopulmonary Pathology Study Group
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Pathology
Issued Date
2014
Volume
48
Issue
1
Keyword
Anaplastic lymphoma kinaseGene rearrangementLung neoplasmsGuideline
Abstract
Rearrangement of anaplastic lymphoma kinase (ALK) gene is the best predictor of response to crizotinib, an ALK tyrosine kinase inhibitor. However, the prevalence of the ALK fusion is low, so accurate patient identification is crucial for successful treatment using ALK inhibitors. Furthermore, most patients with lung cancer present with advanced-stage disease at the time of diagnosis, so it is important for pathologists to detect ALK-rearranged patients while effectively maximizing small biopsy or cytology specimens. In this review, we propose a guideline recommendation for ALK testing approved by the Cardiopulmonary Pathology Study Group of the Korean Society of Pathologists.

Keywords: Anaplastic lymphoma kinase, Gene rearrangement, Lung neoplasms, Guideline
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Hyojin Kim et al. (2014). Guideline Recommendations for Testing of ALK Gene Rearrangement in Lung Cancer: A Proposal of the Korean Cardiopulmonary Pathology Study Group. Korean Journal of Pathology, 48(1), 1–9. doi: 10.4132/KoreanJPathol.2014.48.1.1
Type
Article
ISSN
1738-1843
DOI
10.4132/KoreanJPathol.2014.48.1.1
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34611
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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