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IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma

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Author(s)
Ji Young ParkMisun ChoeYuna KangSang Sook Lee
Keimyung Author(s)
Choe, Mi SunKang, Yu NaLee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Pathology
Issued Date
2014
Volume
48
Issue
2
Keyword
Carcinomarenal cellIMP3Tumor suppressor protein p53Ki-67Neoplasm metastasis
Abstract
Background

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma (RCC), we investigated the expression of IMP3, p53, and Ki-67, and their associations with clinicopathologic outcomes.


Methods

We studied 148 clear cell RCCs (CCRCCs) from patients who underwent radical nephrectomy. The expression levels of IMP3, p53, and Ki-67 were assessed by immunohistochemical staining and the clinical and pathologic parameters were retrospectively reviewed.


Results

Twenty-nine percent of CCRCCs expressed IMP3. Forty-one percent of IMP3-immunopositive tumors developed metastases, while only 11.4% of IMP3-negative tumors developed metastases (p<.001). A Kaplan-Meier curve showed that patients with IMP3-immunopositive tumors had lower metastasis-free survival and cancer-specific survival than did those with IMP3-immunonegative tumors (p<.001 and p<.001, respectively). Expression of high Ki-67 proliferation index was also associated with a higher metastatic rate. In the multivariate Cox regression analysis, pT stage and IMP3-positivity were independently associated with disease-specific survival.


Conclusions

IMP3 is an independent prognostic biomarker for patients with CCRCC to predict metastasis and poor outcome.

Keywords: Carcinoma, renal cell; IMP3; Tumor suppressor protein p53; Ki-67; Neoplasm metastasis
Keimyung Author(s)(Kor)
최미선
강유나
이상숙
Publisher
School of Medicine
Citation
Ji Young Park et al. (2014). IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma. Korean Journal of Pathology, 48(2), 108–116. doi: 10.4132/KoreanJPathol.2014.48.2.108
Type
Article
ISSN
1738-1843
DOI
10.4132/KoreanJPathol.2014.48.2.108
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34612
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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