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Use of Calretinin, CD56, and CD34 for Differential Diagnosis of Schwannoma and Neurofibroma

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Author(s)
Ji Young ParkHoon ParkNam Jo ParkJune Sik ParkHyun-Jung SungSang Sook Lee
Keimyung Author(s)
Lee, Sang Sook
Department
Dept. of Pathology (병리학)
Journal Title
Korean Journal of Pathology
Issued Date
2011
Volume
45
Issue
1
Keyword
SchwannomaNeurofibromaImmunohistochemistryDiagnosisdifferential
Abstract
BACKGROUND: It is important to differentiate between schwannomas and neurofibromas for the cases in which the histopathologic features overlap. Depending on the tumor type, surgeons can decide on a treatment method and whether to preserve or sacrifice the nerve; the possibility of malignant transformation in the case of neurofibromas also needs to be considered. METHODS: We studied 101 cases of schwannoma and 103 cases of neurofibroma. All the hematoxylin and eosin slides for these cases were reviewed, and tissue microarrays were prepared from the representative areas. Immunohistochemical analysis was performed using antibodies for S-100 protein, calretinin, CD56 and CD34. RESULTS: All the tumors except 3 neurofibromas were positive for the S-100 protein. Calretinin was found in 26.7% of the schwannomas (27/101), but it was not found in any of the neurofibromas. CD56 was positive in 77.2% of the schwannomas (78/101) and in 9.8% of the neurofibromas (10/102). CD34 was positive in 42.5% of the schwannomas (43/101) and in 80.2% of the neurofibromas (81/101). Statistically, calretinin was significantly specific for schwannomas (p<0.001) and CD56 was also sensitive for these tumors (p<0.001). On the other hand, a CD34 expression seemed highly sensitive (p<0.001) for neurofibromas. CONCLUSIONS: We concluded that combined immunohistochemical analysis for calretinin, CD56, and CD34 may be very useful for differentiating schwannomas from neurofibromas.
Key Words: Schwannoma; Neurofibroma; Immunohistochemistry; Diagnosis, differential
Keimyung Author(s)(Kor)
이상숙
Publisher
School of Medicine
Citation
Ji Young Park et al. (2011). Use of Calretinin, CD56, and CD34 for Differential Diagnosis of Schwannoma and Neurofibroma. Korean Journal of Pathology, 45(1), 30–35. doi: 10.4132/KoreanJPathol.2011.45.1.30
Type
Article
ISSN
1738-1843
DOI
10.4132/KoreanJPathol.2011.45.1.30
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34614
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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