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Effect of Sedative Dose of Propofol on Neuronal Damage after Transient Forebrain Ischemia in Mongolian Gerbils

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Author(s)
Seong-Ryong Lee
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Journal Title
Korean J of Physiology & Pharmacology
Issued Date
2000
Volume
4
Issue
1
Keyword
PropofolSubanesthetic doseGlobal ischemiaHippocampusNeuroprotectionGerbil
Abstract
This study investigated whether propofol, an intravenous, non-barbiturate anesthetic, could reduce brain damage following global forebrain ischemia. Transient global ischemia was induced in gerbils by occlusion of bilateral carotid arteries for 3 min. Propofol (50 mg/kg) was administered intraperitoneally 30 min before, immediately after, and at 1 h, 2 h, 6 h after occlusion. Thereafter, propofol was administered twice daily for three days. Treated animals were processed in parallel with ischemic animals receiving 10% intralipid as a vehicle or with sham-operated controls. In histologic findings, counts of viable neurons were made in the pyramidal cell layer of the hippocampal CA1 area 4 days after ischemia. The number of viable neurons in the pyramidal cell layer of CA1 area was similar in animals treated with a vehicle or a subanesthetic dose of propofol. In terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick end-labeling (TUNEL) assay, semiquantitative analysis of dark-brown neuronal cells was made in the hippocampal CA1 area. There was no significant difference in the degree of TUNEL staining in the hippocampal CA1 area between vehicle-treated and propofol-treated animals. These results show that subanesthetic dose of propofol does not reduce delayed neuronal cell death following transient global ischemia in Mongolian gerbils.
Keimyung Author(s)(Kor)
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Publisher
School of Medicine
Citation
Seong-Ryong Lee. (2000). Effect of Sedative Dose of Propofol on Neuronal Damage after Transient Forebrain Ischemia in Mongolian Gerbils. Korean J of Physiology & Pharmacology, 4(1), 73–79.
Type
Article
ISSN
1226-4512
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34618
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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