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Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats

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Author(s)
Ji-Young JungMootaek RohKyung-Kyun KoHwan-Soo JangSeong-Ryong LeeJeoung-Hee HaIl-Sung JangHo-Won LeeMaan-Gee Lee
Keimyung Author(s)
Lee, Seong Ryong
Department
Dept. of Pharmacology (약리학)
Journal Title
Korean J of Physiology & Pharmacology
Issued Date
2012
Volume
16
Issue
4
Keyword
DonepezilElectroencephalographyGalantamineMemantineSleep-wake state
Abstract
We studied the effects of acetylcholinesterase inhibitors, donepezil and galantamine, and an N-methyl-D-aspartate (NMDA) receptor blocker, memantine, on sleep-wake architecture in rats. Screw electrodes were chronically implanted into the frontal and parietal cortex for the electroencephalography (EEG). EEG was recorded with a bio-potential amplifier for 8 h from 09:30 to 17:30. Vibration was recorded to monitor animal activity with a vibration measuring device. Sleep-wake states such as wake (W), slow-wave sleep (S) and paradoxical or rapid eye movement sleep (P), were scored every 10 sec by an experimenter. We measured mean episode duration and number of episode to determine which factor sleep disturbance was attributed to. Donepezil and memantine showed a significant increase in total W duration and decreases in total S and P duration and delta activity. Memantine showed increases in sleep latency and motor activity. Changes of S and P duration in memantine were attributed from changes of mean episode duration. Galantamine had little effect on sleep architecture. From these results, it is showed that galantamine may be an anti-dementia drug that does not cause sleep disturbances and memantine may be a drug that causes severe sleep disturbance.

Keywords: Donepezil, Electroencephalography, Galantamine, Memantine, Sleep-wake state
Keimyung Author(s)(Kor)
이성용
Publisher
School of Medicine
Citation
Ji-Young Jung et al. (2012). Effects of Single Treatment of Anti-Dementia Drugs on Sleep-Wake Patterns in Rats. Korean J of Physiology & Pharmacology, 16(4), 231–236. doi: 10.4196/kjpp.2012.16.4.231
Type
Article
ISSN
1226-4512
DOI
10.4196/kjpp.2012.16.4.231
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34619
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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