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Expression of Natriuretic Peptide mRNAs in Isoproterenol-Induced Cardiac Hypertrophy in Rats

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Author(s)
Soo-kyung KimGee-youn KwonEun-sook Chang
Keimyung Author(s)
Kim, Soo KyungChang, Eun Sook
Department
Dept. of Pharmacology (약리학)
Dept. of Pathology (병리학)
Cardiovascular Research Center (심혈관연구소)
Journal Title
Korean J of Physiology & Pharmacology
Issued Date
2000
Volume
4
Issue
3
Keyword
Atrial natriuretic peptideBrain natriuretic peptideCardiac hypertrophyIsoproterenol
Abstract
We examined the expression of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) mRNAs upon isoproterenol (Iso)-induced cardiac hypertrophy in rats. Then, we tried to investigate the effects of sympatholytics to see if they can modulate the expression of ANP and BNP. In this study, RT-PCR technique was used to characterize the expression of ANP and BNP in right atrium (RA) and left ventricle (LV) of the hypertrophied rat heart. Histologic findings indicated that stimulation of ${\beta}-adrenoceptors$ 수식 이미지 with Iso for 5 days was sufficient to induce cardiac hypertrophy in rats. A continuous stimulation with Iso for 7 days resulted in an increase of the ANP and BNP expression in the LV and BNP expression in the RA. The increased expressions of ANP and BNP in the LV were slightly inhibited, and the increased expressions of BNP in the RA were markedly inhibited by a continuous treatment with propranolol, metoprolol, and clonidine for 7 days. Overall, our data present a differential expression of the natriuretic peptides in Iso-induced cardiac hypertrophy, and that the mechanisms involved in this differential ANP and BNP gene expression could be mediated via sympathetic nervous system.


keywords:
Atrial natriuretic peptide; Brain natriuretic peptide; Cardiac hypertrophy; Isoproterenol
Keimyung Author(s)(Kor)
김수경
장은숙
Publisher
School of Medicine
Citation
Soo-kyung Kim et al. (2000). Expression of Natriuretic Peptide mRNAs in Isoproterenol-Induced Cardiac Hypertrophy in Rats. Korean J of Physiology & Pharmacology, 4(3), 235–241.
Type
Article
ISSN
1226-4512
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34620
Appears in Collections:
3. Research Institutues (연구소) > Cardiovascular Research Center (심혈관연구소)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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