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Mediation of N-methyl-D-aspartate on Neuropeptide Y Expression Induced by Morphine in Mouse Cerebellum

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Author(s)
Gee-youn KwonSoo-kyung Kim
Keimyung Author(s)
Kim, Soo Kyung
Department
Dept. of Pharmacology (약리학)
Journal Title
Korean J of Physiology & Pharmacology
Issued Date
2001
Volume
5
Issue
6
Keyword
NPYMorphineNMDACerebellumMouse
Abstract
The existence of opioid receptors in mammalian cerebellum except human, has not been clearly understood. In the present study, we found that NPY was inducible by morphine in the mouse cerebellar granular and Purkinje cell layers. We performed in situ RT-PCR and immunohistochemistry to characterize the NPY expression. The increase of NPY gene expression by morphine (30 mg/kg, i.p.) was inhibited by pretreatment with not only naloxone (100 mg/kg, i.p.) but also a noncompetitive NMDA antagonist, MK-801 (0.3 mg/kg, i.p.). The competitive NMDA antagonist, AP-5 (0.9 mg/kg, i.p.) slightly attenuated the increased NPY expression by morphine. Also, the finding similar to morphine was shown by NMDA (70 mg/kg, i.p.) treatment. Our results indicate that NPY was inducible by morphine and this might reflect activation of NMDA receptors in granule cells that relay mossy fiber inputs to Purkinje cells via parallel fibers.


keywords:
NPY; Morphine; NMDA; Cerebellum; Mouse
Keimyung Author(s)(Kor)
김수경
Publisher
School of Medicine
Citation
Gee-youn Kwon and Soo-kyung Kim. (2001). Mediation of N-methyl-D-aspartate on Neuropeptide Y Expression Induced by Morphine in Mouse Cerebellum. Korean J of Physiology & Pharmacology, 5(6), 479–485.
Type
Article
ISSN
1226-4512
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34621
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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