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Neurotrophic and Neuritogenic Effects of Water Extracts of Rhizoma of Coptis chinensis Franch in PC12 Cells

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Author(s)
Gee-Youn KwonByung-Kil ChoeSoo-Kyung Kim
Keimyung Author(s)
Kim, Soo KyungChoe, Byung Kil
Department
Dept. of Pharmacology (약리학)
Dept. of Immunology (면역학)
Journal Title
Korean J of Physiology & Pharmacology
Issued Date
2003
Volume
7
Issue
3
Keyword
Coptis chinensisNeurite outgrowthPC12 cells
Abstract
Coptis chinensis (CC) is one of the traditional herbs used in Oriental medicine for the treatment of gastrointestinal disorders, anxiety, and insomnia. In this study, neurotrophic and neuritogenic effects of CC on rat pheochromocytoma (PC12) cells were evaluated. Pretreatment of PC12 cells with water extracts of CC (120ug/ml) produced considerable outgrowth of neurites that is comparable to the effect of nerve growth factor (NGF). Therefore, neurite outgrowth was quantified and expression of NGF mRNA was examined. Furthermore, characteristics of neurites were immunocytochemically confirmed using axon and dendrite-specific antibodies. These results suggest that water extracts of CC contain components that have neurotrophic and neuritogenic properties.


key words:
Coptis chinensis; Neurite outgrowth; PC12 cells
Keimyung Author(s)(Kor)
김수경
최병길
Publisher
School of Medicine
Citation
Gee-Youn Kwon et al. (2003). Neurotrophic and Neuritogenic Effects of Water Extracts of Rhizoma of Coptis chinensis Franch in PC12 Cells. Korean J of Physiology & Pharmacology, 7(3), 175–179.
Type
Article
ISSN
1226-4512
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34623
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Pharmacology (약리학)
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