계명대학교 의학도서관 Repository

How long should patients remain in the supine treatment position after intratympanic dexamethasone injection?

Metadata Downloads
Author(s)
Soon H. ParkChanghun ParkJin Y. SeoJae H. ChoIn S. Moon
Keimyung Author(s)
Park, Soon Hyung
Department
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Laryngoscope
Issued Date
2014
Volume
124
Issue
12
Keyword
Intratympanicpositionsudden hearing loss
Abstract
Objectives/Hypothesis

Intratympanic dexamethasone injection (ITDI) is a widely accepted treatment for patients with sudden hearing loss. We investigated the appropriate patient wait time in the supine treatment position after ITDI.


Study Design


Prospective study.


Methods


In an in vivo animal study, 24 mice were injected intratympanically with dexamethasone. Perilymphatic fluid was sampled at 5, 10, 15, 20, 25, and 30 minutes postinjection. The dexamethasone concentration was analyzed using high-performance liquid chromatography. In a separate prospective clinical study, 79 patients with refractory sudden hearing loss underwent intratympanic injection. After the injection, patients remained in the supine position with the head rotated 45° to the unaffected side. Patients were divided into two groups according to the wait time in this treatment position postinjection: 30 minutes (n = 47) and 10 minutes (n = 32). Final hearing assessments were conducted 2 months after salvage treatment.


Results


In the in vivo animal study, the perilymphatic concentration of dexamethasone showed no significant increase after 10 minutes. In the clinical setting, hearing improvement according to Siegel's criteria was similar in the 30-minute (14/47) and 10-minute (10/32) groups (P = 0.999). No significant differences in relative hearing gain was observed between the two groups (13.80 ± 19.9 dB and 12.57 ± 14.9 dB, respectively; P = 0.766).


Conclusion


We suggest that 10 minutes is a sufficient time to remain in the supine treatment position after ITDI in patients with sudden hearing loss.


Level of Evidence


N/A. Laryngoscope, 124:2807–2810, 2014
Keywords:

Intratympanic;
position;
sudden hearing loss
Keimyung Author(s)(Kor)
박순형
Publisher
School of Medicine
Citation
Soon H. Park et al. (2014). How long should patients remain in the supine treatment position after intratympanic dexamethasone injection? Laryngoscope, 124(12), 2807–2810. doi: 10.1002/lary.24872
Type
Article
ISSN
0023-852X
Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/lary.24872
DOI
10.1002/lary.24872
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34635
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.