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Lipid MALDI MS Profiles of Gastric Cancer

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Author(s)
Sun Young KwonSeung Ho ChoiYoung Soo ParkDo Youn ParkYoung Iee ParkIlseon HwangMin Hee RyuChae Hwa KwonJeong Hwa LeeGeul BangKwang Pyo KimYoung Hwan KimHark Kyun Kim
Keimyung Author(s)
Kwon, Sun YoungHwang, Il SeonKim, Young Hwan
Department
Dept. of Pathology (병리학)
Dept. of Radiology (영상의학)
Journal Title
open proteomics Journal
Issued Date
2014
Volume
7
Issue
1
Keyword
Gastric cancerlipidMALDIprofile
Abstract
Tissue matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS)may identify lipids
differentially expressed between cancer and adjacent normal tissue. To identify lipidomic profiles for gastric cancer, 24
gastric cancerswere profiled for lipid by the histology-directed, tissue MALDI MS technology. Lipid profiles differed
between gastric cancer and adjacent normal tissue samples. At P<0.05, median class prediction accuracy in 100 random
training-to-test partitions was 83.3% (5/6) for all classifiers tested. A peak at m/z 741.6 (sphingomyelin 34:1 K) was
overexpressed, and a peak at m/z 782.6 (phosphatidylcholine 34:1 Na) was underexpressed in gastric cancers compared
with normal tissue. Thus, lipid MALDI MS analysis may capture a global alteration in lipid profile of gastric cancer
tissue, distinguishing cancerous epithelium from normal epithelium.
Keywords: Gastric cancer, lipid, MALDI, profile.
Keimyung Author(s)(Kor)
권선영
황일선
김영환
Publisher
School of Medicine
Citation
Sun Young Kwon et al. (2014). Lipid MALDI MS Profiles of Gastric Cancer. open proteomics Journal, 7(1), 1–4. doi: 10.2174/1875039701407010001
Type
Article
ISSN
1875-0397
Source
https://linkinghub.elsevier.com/retrieve/pii/S1874-3919(13)00044-4
DOI
10.2174/1875039701407010001
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34641
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
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