계명대학교 의학도서관 Repository

Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation

Metadata Downloads
Author(s)
Hui-Hun KimSeung-Bin ParkSoyoung LeeTaeg Kyu KwonTae-Yong ShinPil-Hoon ParkSeung-Ho LeeSang-Hyun Kim
Keimyung Author(s)
Kwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
Toxicology and Applied Pharmacology
Issued Date
2014
Volume
274
Issue
3
Keyword
Allergic inflammationMast cellsHistaminePutranjivain ANF-κBNFAT
Abstract
A great number of people are suffering fromallergic inflammatory disease such as asthma, atopic dermatitis, and sinusitis. Therefore discovery of drugs for the treatment of these diseases is an important subject in human health. Putranjivain A (PJA), member of ellagitannin, is known to possess beneficial effects including anticancer and anti-viral activities. The aimof the present studywas to elucidate whether PJAmodulates the allergic inflammatory reaction and to study its possible mechanisms of action using mast cell-based in vitro and in vivo models. The studywas performed in anaphylaxismousemodel and culturedmast cells. PJA inhibited the expression of pro-inflammatory cytokines in immunoglobulin E-stimulated mast cells. PJA reduced this expression by inhibiting nuclear factor (NF)-κB and nuclear factor of activated T cell. The oral administration of PJA reduced systemic and cutaneous anaphylaxis, the release of serumhistamine, and the expression of the histamine H1 receptor. In addition, PJA attenuated the activation of mast cells. PJA inhibited the release of histamine from various types of mast cells by the suppression of intracellular calcium. The inhibitory activity of PJA on the allergic reaction was similar to that of disodiumcromoglycate, a known anti-allergic drug. These results suggest that PJA can facilitate the prevention or treatment of allergic inflammatory diseases mediated by mast cells.
© 2013 Elsevier Inc. All rights reserved. Keywords:
Allergic inflammation
Mast cells
Histamine
Putranjivain A
NF-κB
NFAT
Keimyung Author(s)(Kor)
권택규
Publisher
School of Medicine
Citation
Hui-Hun Kim et al. (2014). Inhibitory effect of putranjivain A on allergic inflammation through suppression of mast cell activation. Toxicology and Applied Pharmacology, 274(3), 455–461. doi: 10.1016/j.taap.2013.12.006
Type
Article
ISSN
0041-008X
Source
https://www.sciencedirect.com/science/article/pii/S0041008X13005590?via%3Dihub
DOI
10.1016/j.taap.2013.12.006
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34664
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.