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Loss of BRCA1 leads to an increased sensitivity to Bisphenol A

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Author(s)
Laundette P. JonesAishia SampsonHyo Jin KangHee Jeong KimYong-Weon YiSun Young KwonJanice K. BabusAntai WangInsoo Bae
Keimyung Author(s)
Kwon, Sun Young
Department
Dept. of Pathology (병리학)
Journal Title
Toxicology Letters
Issued Date
2010
Volume
199
Issue
3
Keyword
Brca1Mammary glandBisphenol AMice
Abstract
Humans are chronically exposed to the plasticizer, Bisphenol A (BPA), that can adversely affect the normal
hormonal regulation of cellular functions by mimicking the actions of estrogen. This biological response
to BPA may vary according to an individual’s genetic characteristics (e.g., BRCA1 mutations or deletion).
In this study, both cell culture and mouse models were used to elucidate whether the loss of BRCA1
function could affect BPA-mediated cell proliferation. In studies using BPA levels comparable to human
exposures,we found that loss of BRCA1 enhances BPA-induced cell proliferation in both systems. In vitro,
we found that loss of BRCA1 enhances BPA-induced ER signaling. In vivo, we found that BPA admin-
istration stimulates mammary gland epithelial tissue/cell proliferation leading to hyperplasia in Brca1
mutant mice compared to wild-type control mice. These results suggest that the biological responses in
BRCA1-deficient cells may depend on environmental exposures, specifically BPA.
© 2010 Elsevier Ireland Ltd. All rights reserved Keywords:
Brca1
Mammary gland
Bisphenol A
Mice
Keimyung Author(s)(Kor)
권선영
Publisher
School of Medicine
Citation
Laundette P. Jones et al. (2010). Loss of BRCA1 leads to an increased sensitivity to Bisphenol A. Toxicology Letters, 199(3), 261–268. doi: 10.1016/j.toxlet.2010.09.008
Type
Article
ISSN
0378-4274
DOI
10.1016/j.toxlet.2010.09.008
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34675
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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