계명대학교 의학도서관 Repository

Polyphenol (-)-Epigallocatechin Gallate Protection from Ischemia/Reperfusion-Induced Renal Injury in Normotensive and Hypertensive Rats

Metadata Downloads
Affiliated Author(s)
최미선이미영이성용장영호이용철김애라김진모문교철박남희
Alternative Author(s)
Choe, Mi SunLee, Mi YoungJang, Young HoLee, Yong CheolKim, Ae RaKim, Jin MoMun, Kyo CheolPark, Nam HeeLee, Seong Ryong
Journal Title
Transplantation Proceedings
ISSN
0041-1345
Issued Date
2006
Abstract
Introduction. The effect of epigallocatechin gallate (EGCG) in an in vivo renal model of
ischemia with reperfusion (I/R) was compared between normotensive (WKR) and
hypertensive (SHR) rats.
Methods. WKR (groups I, II, III) and SHR groups (groups IV, V, VI) were divided into
three types. Groups I and IV were sham-operated animals; groups II and V were subjected
to 45 minutes of renal I/R; and groups III and VI received 10 mg/kg EGCG intravenously
at the time of reperfusion. Three days after renal I/R, we compared renal function
markers, malondialdehyde (MDA), and histologic changes.
Results. Following renal I/R, levels of blood urea nitrogen (BUN) and serum creatinine
(sCr) were increased and serum creatinine clearance (CrCl) decreased in group V
compared to group II (P .001). Those receiving EGCG treatment (groups III and VI)
had decreased BUN and sCr compared to non-EGCG I/R groups (P .001), but not
surprisingly, higher than sham groups. CrCl was lowest in the SHR groups. The MDA was
significantly decreased after EGCG treatment (P .028 in group III, P .002 in group
VI). Following renal I/R, tissue necrosis was more severe among SHR (P .001).
However, the ratio of regeneration to damage significantly increased in SHR after EGCG
treatment.
Conclusions. The reperfusion injury was greater among SHR compared with WKR in
terms of renal function, lipid peroxidation, and tissue damage. EGCG treatment significantly
ameliorated renal impairment and promoted tissue regeneration following renal I/R.
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.