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BK Virus Infection in Renal Allograft Recipients

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Author(s)
Y.N. KangS.M. HanK.K. ParkD.S. JeonH.C. Kim
Keimyung Author(s)
Jeon, Dong SeokKang, Yu NaPark, Kwan KyuKim, Hyun Chul
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Pathology (병리학)
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Transplantation Proceedings
Issued Date
2003
Volume
35
Issue
1
Abstract
BK VIRUS, a nonenveloped, double-strand DNA virus,
is one of the widely spread human polyoma viruses.
BK virus infection is associated with disease in humans. In
healthy individuals, BK virus resides in a latent state in the
kidney and can be activated without functional impairment
or ill effects. But BK virus causes disease more frequently in
immunosuppression patients, including those with AIDS or
renal transplants. Three renal allografted patients with high
serum creatinine values presented clinical symptoms of
rejection. Cells containing viral inclusion bodies (decoy
cells) were detected in the urine cytology. Sections of renal
allograft biopsy tissue showed infiltration of mononuclear
cells in the tubulointerstitium and nuclear enlargement with
inclusions in the tubular epithelium. Immunohistochemical
stains for SV40 antigen showed positive nuclear staining in
BK virus-infected tubular epithelium. Electron microscopy
showed paracrystalline arrays of naked viral particles with a
diameter 45 nm. BK virus infection in renal allograft
recipients has become more frequent since the prescription
of new immunosuppressive agents. The morphologic char-
acteristics and the diagnostic methods for BK virus infec-
tion must be analyzed. Although asymptomated BK virus
infection has been documented by urine cytology, other
diagnostic tools as well as the clinical course of biopsy-
proven interstitial nephritis have not been well defined.
Keimyung Author(s)(Kor)
전동석
강유나
박관규
김현철
Publisher
School of Medicine
Citation
Y.N. Kang et al. (2003). BK Virus Infection in Renal Allograft Recipients. Transplantation Proceedings, 35(1), 275–277. doi: 10.1016/S0041-1345(02)03954-4
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134502039544?via%3Dihub
DOI
10.1016/S0041-1345(02)03954-4
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34711
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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