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Cyclosporine-Induced Apoptosis in Osteosarcoma Cells

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Author(s)
Y.L. OhS.Y. HanK.H. MunH.J. ChoiH.Y. KimE.A. HwangS.B. ParkH.C. KimE.J. Chang
Keimyung Author(s)
Han, Seung YeupHwang, Eun AhPark, Sung BaeKim, Hyun Chul
Department
Dept. of Internal Medicine (내과학)
Kidney Institute (신장연구소)
Journal Title
Transplantation proceeding
Issued Date
2006
Volume
38
Issue
7
Abstract
Introduction. Posttransplant bone disease is one of the complications of cyclosporine
(CsA), which is widely used as an immunosuppressive agent in the field of kidney
transplantation. Cyclosporine treatment causes osteopenia as a result of altered bone
turnover, but the pathogenic mechanisms of this process remain unclear. This study
examined the ability of CsA to induce apoptosis in a rat osteoblast cell line.
Results. We induced apoptosis in rat osteoblastic ROS 17/2.8 cells by exposure to CsA.
MTT assay showed that CsA exhibited significant cytotoxic effects on ROS 17/2.8 cells in a
dose-dependent manner.Western blot analysis showed enhanced processing of caspase-8, Bax,
and p53 after CsA treatment. Expression of cleaved poly (ADP-ribose) polymerase (PARP)
was elevated by CsA treatment. Pro-caspase-3 and Bcl-2 proteins were decreased by CsA.
Conclusions. These results suggested that CsA induced apoptosis of osteoblasts.
Keimyung Author(s)(Kor)
한승엽
황은아
박성배
김현철
Publisher
School of Medicine
Citation
Y.L. Oh et al. (2006). Cyclosporine-Induced Apoptosis in Osteosarcoma Cells. Transplantation proceeding, 38(7), 2237–2239. doi: 10.1016/j.transproceed.2006.06.025
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134506006439?via%3Dihub
DOI
10.1016/j.transproceed.2006.06.025
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34716
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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