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BK Virus Infection in Kidney Transplant Recipients

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Author(s)
H.C. KimE.A. HwangM.J. KangS.Y. HanS.B. ParkK.K. Park
Keimyung Author(s)
Kim, Hyun ChulHwang, Eun AhHan, Seung YeupPark, Sung BaePark, Kwan Kyu
Department
Dept. of Internal Medicine (내과학)
Dept. of Pathology (병리학)
Kidney Institute (신장연구소)
Journal Title
Transplantation Proceeding
Issued Date
2004
Volume
36
Issue
7
Abstract
Introduction. Nephropathy associated with the polyomavirus type BK virus (BKV) has
emerged as a cause of allograft failure linked to immunosuppressive regimens containing
tacrolimus or mycophenolate mofetil (MMF). The outcome in BKV nephropathy is
generally unfavorable, namely 50% of patients lose graft function. We herein report nine
cases of BKV nephropathy after kidney transplantation.
Methods. From October 1998 to May 2003, 138 of 169 consecutive kidney transplant
patients received tacrolimus-based immunosuppression, and 31 received cyclosporine-
based immunosuppression. Additionally, 88.2% of the patients received mycophenolate
mofetil (MMF). The diagnosis of BK infection was made by the presence of decoy cells in
the urine and by allograft biopsy.
Results. There were nine cases of BKV nephropathy in kidney transplant recipients, an
incidence of 5.3%. All patients with BKV nephropathy received tacrolimus, MMF, and
steroids. The median time to diagnosis of BKV infection was 7.8 months after transplan-
tation. All patients experienced an elevated serum creatinine, which stabilized or
decreased in seven patients with altered or decreased immunosuppression. After a mean
follow-up of 11.1 months, 2 (22.2%) of nine patients lost the graft.
Conclusion. Because BKV nephropathy is a rare but serious complication after
kidney transplantation, it should be included in the clinical differential of transplant
dysfunction. In the absence of documented antiviral treatment, early diagnosis and
judicious use of immunosuppressive agents is indicated to minimize the occurrence of
BKV infection.
Keimyung Author(s)(Kor)
김현철
황은아
한승엽
박성배
박관규
Publisher
School of Medicine
Citation
H.C. Kim et al. (2004). BK Virus Infection in Kidney Transplant Recipients. Transplantation Proceeding, 36(7), 2113–2115. doi: 10.1016/j.transproceed.2004.08.007
Type
Article
ISSN
0041-1345
Source
https://linkinghub.elsevier.com/retrieve/pii/S0041134504008620
DOI
10.1016/j.transproceed.2004.08.007
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34722
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
3. Research Institutues (연구소) > Kidney Institute (신장연구소)
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