계명대학교 의학도서관 Repository

Comparison Between Resection and Transplantation in Combined Hepatocellular and Cholangiocarcinoma

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Author(s)
S. SongH.H. MoonS. LeeT.-S. KimM. ShinJ.M. KimJ.B. ParkC.H.D. KwonS.J. KimS.-K. LeeJ.-W. Joh
Keimyung Author(s)
Kim, Tae Seok
Department
Dept. of Surgery (외과학)
Journal Title
Transplantation proceedings
Issued Date
2013
Volume
45
Issue
8
Abstract
Objective

The treatment of choice for combined hepatocellular and cholangiocarcinoma (cHCC-CC) is surgical resection. However, the efficacy of liver transplantation is not clear. We compared the surgical outcome of hepatic resection and liver transplantation for cHCC-CC.

Patients and methods

From 1995 to 2012, 89 patients were diagnosed with cHCC-CC after hepatic resection and 8 patients diagnosed with cHCC-CC after liver transplantation. We excluded 21 patients who were American Joint Committee on Cancer Staging Stage III or IV and lost to follow-up. The outcomes were reviewed retrospectively.

Results

The poor prognostic factors in cHCC-CC patients who underwent hepatectomy were large tumor size (>5 cm), small safety margin (<2 cm), and low preoperative albumin level. The disease-free survival (DFS) and overall survival (OS) between the hepatectomy group (n = 68) and the liver transplant group (n = 8) was not statistically different (5-year DFS: 26.2% vs 37.5%, P = .333; 5-year OS: 42.1% vs 50%, P = .591). In the small tumor subgroup (tumor size <5 cm), the DFS and OS between the 2 surgical procedures was not different, and in the adequate resection margin subgroup (safety margin >2 cm), survival was comparable.

Conclusions

In well-selected cases with small tumor size and with preserved liver function, liver resection should be considered when complete resection is possible.
Keimyung Author(s)(Kor)
김태석
Publisher
School of Medicine
Citation
S. Song et al. (2013). Comparison Between Resection and Transplantation in Combined Hepatocellular and Cholangiocarcinoma. Transplantation proceedings, 45(8), 3041–3046–3041–3046. doi: 10.1016/j.transproceed.2013.08.064
Type
Article
ISSN
0041-1345
Source
https://www.sciencedirect.com/science/article/pii/S0041134513008683?via%3Dihub
DOI
10.1016/j.transproceed.2013.08.064
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34734
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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