Long-Term Outcome of IgA Nephropathy in Living Related Kidney Transplantation

Abstract

Immunoglobin a nephropathy (IgAN) has a high recurrence rate in recipients of living-related transplants. Usually, the clinical course of recurrent IgAN has been benign, rarely causing allograft loss.1 However, recent studies have reported that recurrent IgAN induces or is associated with chronic graft dysfunction in up to 20% of the recipients.1, 2, 3, 4 and 5 Usually, chronic allograft dysfunction has a multifactorial origin and results from both immunologic and nonimmune mechanisms. Allograft kidney biopsy findings and clinical data can allow the differentiation between contribution of chronic renal allograft dysfunction due to recurrent disease and other reasons. Practically, clear-cut differentiation of chronic allograft dysfunction has many difficulties in kidney transplant recipients. We performed single-center analysis of the long-term results of allograft survival, and clinical course was examined in living-donor kidney transplant recipients with IgAN.