계명대학교 의학도서관 Repository

Expression of JL1 in Burkitt lymphoma is associated with improved overall survival

Metadata Downloads
Author(s)
Ilseon HwangHeounjeong GoYoon Kyung JeonYoung Hyeh KoDok Hyun YoonCheolwon SuhJoo Ryung HuhHyangsin LeeMinchan GilChan-Sik Park
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
Virchows Archiv
Issued Date
2011
Volume
459
Issue
4
Keyword
JL1Burkitt lymphomaPredictive factorPrognosisImmunohistochemistry
Abstract
JL1 is a novel molecule expressed in the surface of
hematopoietic precursor cells, but not on any other mature
human tissue. Accordingly, JL1 is expressed in acute lympho-
blastic leukemia (ALL) cells and can be used both for specific
diagnosis and as a target for treatment. However, expression of
JL1 by lymphomas has not been thoroughly assessed. Burkitt
lymphoma is a potentially curable aggressive lymphoma, but
prognostic markers that stratify risk have not been established.
We therefore assayed JL1 expression in Burkitt lymphoma
patients to assess its value as a prognostic marker for this
disease. Tissue microarray blocks of formalin-fixed paraffin-
embedded tissue samples from patients with Burkitt lympho-
ma and other B-cell lymphomas, at the Asan Medical Center
and Seoul National University Hospital from January 1998 to
December 2008 were immunohistochemically assayed using a
mousemonoclonal antibody against JL1.We found that 30.2%
of Burkitt lymphoma samples, but no other lymphoma
samples, were positive for JL1. JL-1 expression was signifi-
cantly correlated with patient survival (P =0.022), but not with
other clinical manifestations of the disease, with 91.6% of
JL1-positive patients achieving complete remission in re-
sponse to chemotherapy and 6.25% experiencing disease
recurrence. JL1 positivity was significantly correlated with
prolonged overall survival by both Kaplan–Meier survival
(P =0.035) and Cox proportional hazard model (P =0.043)
analysis. JL1 expression in Burkitt lymphoma was positively
correlated with overall survival and better response to
chemotherapy, suggesting that JL1 may be a prognostic
marker for risk stratification in these patients.
Keywords: JL1 . Burkitt lymphoma . Predictive factor .
Prognosis . Immunohistochemistry
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine
Citation
Ilseon Hwang et al. (2011). Expression of JL1 in Burkitt lymphoma is associated with improved overall survival. Virchows Archiv, 459(4), 353–359. doi: 10.1007/s00428-011-1134-6
Type
Article
ISSN
0945-6317
Source
https://link.springer.com/article/10.1007%2Fs00428-011-1134-6
DOI
10.1007/s00428-011-1134-6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34798
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.