계명대학교 의학도서관 Repository

Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia

Metadata Downloads
Author(s)
Soo-Hee ChoiHyeongrae LeeJeonghun KuKang Joon YoonJae-Jin Kim
Keimyung Author(s)
Ku, Jeong Hun
Department
Dept. of Biomedical Engineering (의용공학과)
Journal Title
World Journal of Biological Psychiatry
Issued Date
2014
Volume
15
Issue
7
Abstract
Objectives. Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. Methods. A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. Results. A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. Conclusions. Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information. Key words:
Schizophrenia,
anhedonia,
anticipatory pleasure,
anterior cingulate cortex,
caudate
Keimyung Author(s)(Kor)
구정훈
Publisher
School of Medicine
Citation
Soo-Hee Choi et al. (2014). Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia. World Journal of Biological Psychiatry, 15(7), 525~533-525~533. doi: 10.3109/15622975.2013.819121
Type
Article
ISSN
1562-2975
Source
https://www.tandfonline.com/doi/abs/10.3109/15622975.2013.819121?journalCode=iwbp20
DOI
10.3109/15622975.2013.819121
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34809
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biomedical Engineering (의용공학과)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록
  • 관련 파일이 존재하지 않습니다.

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.