Anti-inflammatory effect of quetiapine on collagen-induced arthritis of mouse

Abstract

Quetiapine is an atypical antipsychotic and has also been used in the treatment of depression. Since antiinflammatory effects of antidepressants are well established, we hypothesized that quetiapine may also exert anti-inflammatory effects. Thus this study was designed to examine the anti-inflammatory effect of quetiapine in murine collagen-induced arthritis. Mice were immunized with collagen type II for the induction of arthritis and treated with quetiapine (10 mg/kg) daily for 2 weeks.Mice were divided into 3 groups: control, CIA, and CIA+quetiapine treatment. Arthritic index and paw thickness were used to compare severity of arthritis. In additions, radiological and histological assessments were employed. Anti-type II collagen-specific antibody, interleukin-6 (IL-6), interleukin-17 (IL-17), and prostaglandin E2 (PGE2) were evaluated at the end of the treatment period. Both arthritic index and paw thickness were markedly improved in CIA+quetiapine treatment group compared with those in CIA groups (arthritic index; Pb0.01, paw thickness; Pb0.05). Radiologic assessment revealed decreased cartilage damage and bone erosion in CIA+quetiapine treatment group compared with those in CIA groups. Articular cartilage destruction observed in CIA group was not found in CIA+quetiapine group. The concentrations of anti-type II collagenspecific antibody, IL-6, IL-17, and PGE2 in CIA+quetiapine group were significantly lower than those in CIA groups (Pb0.05). Weight gain which is commonly observed with the treatment of antipsychotics was not observed. Taken together, these results suggest that quetiapine shows anti-inflammatory effects inmurine collagen-induced arthritis. © 2011 Elsevier B.V. All rights reserved.