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한국의 염증성 장질환과 자가면역성 간염 환자에서 Azathioprine의 부작용 비교

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Author(s)
이유진최왕용박경식김윤정조광범김은수장병국정우진황재석
Keimyung Author(s)
Lee, Yoo JinPark, Kyung SikCho, Kwang BumKim, Eun SooJang, Byoung KukChung, Woo JinHwang, Jae Seok
Department
Dept. of Internal Medicine (내과학)
Journal Title
Korean journal of gastroenterology
Issued Date
2014
Volume
64
Issue
6
Abstract
Background/Aims: Azathioprine (AZA) has been widely used in the therapy of inflammatory bowel disease (IBD) and autoimmune
hepatitis (AIH). However, studies evaluating the adverse effects of AZA in these two diseases are lacking. The aim of this
study was to compare the adverse effects of AZA in Korean IBD and AIH patients.
Methods: Patients with IBD or AIH who were treated with AZA at Keimyung University Dongsan Medical Center (Daegu, Korea)
between January 2002 and March 2011 were enrolled. Their medical records were reviewed retrospectively in terms of clinical
characteristics and adverse effects of AZA.
Results: A total of 139 IBD patients and 55 AIH patients were finally enrolled. Thirty IBD patients (21.6%) and eight AIH
patients (14.5%) experienced adverse effects of AZA. In particular, the prevalence of leukopenia was significantly higher in
the IBD group than in the AIH group (p=0.026). T474C mutation was observed in three of 10 patients who were assessed
for thiopurine methyltransferase (TPMT) genotype.
Conclusions: IBD patients are at increased risk for the adverse effects of AZA compared with AIH patients, of which leukopenia
was the most commonly observed. Therefore, IBD patients receiving AZA therapy should be carefully monitored. (Korean J
Gastroenterol 2014;64:348-355)
Key Words: Azathioprine; Inflammatory bowel diseases; Hepatitis, autoimmune; Adverse effects
Alternative Title
Differences in the Adverse Effects of Azathioprine between Inflammatory Bowel Disease and Autoimmune Hepatitis in Korean Patients
Keimyung Author(s)(Kor)
이유진
박경식
조광범
김은수
장병국
정우진
황재석
Publisher
School of Medicine
Citation
이유진 et al. (2014). 한국의 염증성 장질환과 자가면역성 간염 환자에서 Azathioprine의 부작용 비교. Korean journal of gastroenterology, 64(6), 348–355. doi: 10.4166/kjg.2014.64.6.348
Type
Article
ISSN
1598-9992
DOI
10.4166/kjg.2014.64.6.348
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34831
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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