계명대학교 의학도서관 Repository

Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kB and c-Jun NH2-terminal kinase

Metadata Downloads
Author(s)
Young-Ho KimSang-Han LeeJai-Youl LeeSang-Won ChoiJong-Wook ParkTaeg Kyu Kwon
Keimyung Author(s)
Park, Jong WookKwon, Taeg Kyu
Department
Dept. of Immunology (면역학)
Journal Title
European Journal of Pharmacology
Issued Date
2004
Volume
494
Issue
1
Abstract
Triptolide (PG490) is a natural, biologically active compound extracted from the Chinese herb Tripterygium wilfordii. It has been shown to
possess potent anti-inflammatory and immunosuppressive properties. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic
inflammation, triptolide inhibits nitric oxide (NO) production in a dose-dependent manner and abrogates inducible nitric oxide synthase (iNOS)
gene expression. To investigate the mechanism by which triptolide inhibits murine iNOS gene expression, we examined activation of mitogenactivated
protein kinases (MAP kinases) and nuclear factor-nB (NF-nB) in these cells. Addition of triptolide inhibited phosphorylation of c-Jun
NH2-terminal kinase (JNK) but not that of extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein kinase. In addition,
triptolide significantly inhibited the DNA binding activity of NF-nB. Taken together, these results suggest that triptolide acts to inhibit
inflammation through inhibition of NO production and iNOS expression through blockade of NF-nB and JNK activation.
D 2004 Elsevier B.V. All rights reserved.
Keywords: Triptolide; NO (Nitric oxide); iNOS; NF-nB; JNK
Keimyung Author(s)(Kor)
박종욱
권택규
Publisher
School of Medicine
Citation
Young-Ho Kim et al. (2004). Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kB and c-Jun NH2-terminal kinase. European Journal of Pharmacology, 494(1), 1–9. doi: 10.1016/j.ejphar.2004.04.040
Type
Article
ISSN
0014-2999
Source
https://linkinghub.elsevier.com/retrieve/pii/S0014299904004637
DOI
10.1016/j.ejphar.2004.04.040
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34838
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.