호흡기세포융합 바이러스 아형에 따른 영아기 폐렴 및 모세기관지염의 임상 양상: 2010.2012 일개 삼차병원의 경험

Abstract

Purpose: The most common cause of bronchiolitis and pneumonia in infants is respiratory syncytial virus (RSV). We evaluated the clinical characteristics according to RSV subgroup in infantile bronchiolitis and pneumonia. Methods: This study enrolled infants with bronchiolitis or pneumonia infected by single virus. Virus infection was confirmed by respiratory virus reverse transcriptase polymerase chain reaction in two consecutive seasons (2010.2011, 2011.2012). They were divided into 3 groups: group 1 with RSV A, group 2 with RSV B, and group 3 with other virus. We retrospectively reviewed the medical charts to collect data on the hospitalized patients. Results: Seventy four and 181 infants were included in the two seasons, respectively. The most common virus was RSV B in 2010. 2011 and RSV A in 2011.2012. Among 255 infants, 55% (141/255) were group 1, 20% (49/255) group 2, 25% (65/255) group 3. Infants younger than 3 months were 55%. There were no significant age differences between groups. In comparison to group 3, group 1 and 2 showed frequent abnormal chest auscultation, high symptom severity score and need for systemic corticosteroid (P<0.05). In comparison to group 1 and 3, group 2 had longer hospitalization and time to need for normalization of lung sound (P<0.05). The recurrence rates within 6 months showed no significant differences between groups. Conclusion: The RSV subgroup changed from one year to another. Patients’ clinical manifestations and symptom severity may vary according to infected virus subgroup. (Allergy Asthma Respir Dis 1(1):84-89, 2013)