계명대학교 의학도서관 Repository

Macrophage Heterogeneity of Culprit Coronary Plaques in Patients With Acute Myocardial Infarction or Stable Angina

Metadata Downloads
Author(s)
Cheol Whan LeeIlseon HwangChan-Sik ParkHyangsin LeeDuk-Woo ParkSoo-Jin KangSeung-Whan LeeYoung-Hak KimSeong-Wook ParkSeung-Jung Park
Keimyung Author(s)
Hwang, Il Seon
Department
Dept. of Pathology (병리학)
Journal Title
American Journal of Clinical Pathology
Issued Date
2013
Volume
139
Issue
3
Abstract
We investigated the polarization states of
macrophages in coronary atherectomy tissues retrieved
from patients with acute myocardial infarction (AMI,
n = 52) or stable angina pectoris (SAP, n = 22). The
specimens were analyzed immunohistochemically
using antibodies specific to CD11c (M1 marker),
CD206 (M2 marker), and to markers of endothelial
cells, macrophages, and smooth muscle cells. Baseline
characteristics were similar in the 2 groups. The
proportion of areas immunopositive for a smooth
muscle actin was similar, but those positive for CD31
and CD68 were larger in the AMI group compared
with the SAP group. In addition, AMI had significantly
greater areas immunopositive for CD11c (P = .007)
than did SAP, but CD206 (P = .102) positivity
was not different in the 2 groups. In conclusion,
M1 macrophage infiltration, not M2 macrophage
infiltration, was increased in culprit plaques of patients
with AMI. Macrophage heterogeneity may therefore be
related to plaque instability.
Macrophages are heterogeneous and can exist as either
proinflammatory (M1) or anti-inflammatory (M2) types.1-5
M1 macrophages primarily secrete proinflammatory cytokines,
thus amplifying the inflammation. In contrast, M2
macrophages secrete anti-inflammatory cytokines, damping
the inflammatory responses. Therefore, tipping the balance
toward pro- or anti-inflammatory types may affect plaque
stability. However, the relationship between macrophage
heterogeneity and plaque instability remains uncertain. We
investigated the phenotypic heterogeneity of macrophages
in coronary atherectomy tissues obtained from patients with
acute myocardial infarction (AMI) or stable angina pectoris
(SAP) and examined the relationship between their expression
levels and clinical manifestations.
Keimyung Author(s)(Kor)
황일선
Publisher
School of Medicine
Citation
Cheol Whan Lee et al. (2013). Macrophage Heterogeneity of Culprit Coronary Plaques in Patients With Acute Myocardial Infarction or Stable Angina. American Journal of Clinical Pathology, 139(3), 317–322. doi: 10.1309/AJCP7KEYGN3OBGQX
Type
Article
ISSN
0002-9173
DOI
10.1309/AJCP7KEYGN3OBGQX
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34902
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.