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Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury

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Author(s)
Won-Il ChoiDeborah A. QuinnKwon Moo ParkRamzi KMoufarrej, Behrouz JafariOlga SyrkinaJoseph V. BonventreCharles A. Hales
Keimyung Author(s)
Choi, Won Il
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Journal of Respiratory and Critical Care Medicine
Issued Date
2003
Volume
167
Issue
12
Abstract
Positive pressure mechanical ventilation has significant systemic effects, but the systemic effects associated with ventilator-induced lung injury (VILI) are unexplored. We hypothesized that VILI would cause systemic microvascular leak that is dependent on nitric oxide synthase (NOS) expression. Rats were ventilated with room air at 85 breaths/minute for 2 hours with either VT 7 or 20 ml/kg. Kidney microvascular leak, which was assessed by measuring 24-hour urine protein and Evans blue dye, was used as a marker of systemic microvascular leak. A significant microvascular leak occurred in both lung and kidney with large VT (20 ml/kg) ventilation. Injection of 0.9% NaCl corrected the hypotension and the decreased cardiac output related to large VT, but it did not attenuate microvascular leak of lung and kidney. Serum vascular endothelial growth factor was significantly elevated in large VT groups. Endothelial NOS expression significantly increased in the lung and kidney tissue with large VT ventilation but not inducible NOS. The NOS inhibitor, N-nitro-L-arginine methyl ester, attenuated the microvascular leak of lung and kidney and the proteinuria with large VT ventilation. Endothelial NOS may mediate the systemic microvascular leak of the present model of VILI.

KEYWORDS: microvascular leak, permeability, proteinuria, endothelial nitric oxide synthase, N-nitro-L-arginine methyl ester



Read More: http://www.atsjournals.org/doi/abs/10.1164/rccm.200210-1216OC#.VoNdTU8ayAg
Keimyung Author(s)(Kor)
최원일
Publisher
School of Medicine
Citation
Won-Il Choi et al. (2003). Systemic Microvascular Leak in an In Vivo Rat Model of Ventilator-induced Lung Injury. American Journal of Respiratory and Critical Care Medicine, 167(12), 1627–1632. doi: 10.1164/rccm.200210-1216OC
Type
Article
ISSN
1073-450X
Source
https://www.atsjournals.org/doi/abs/10.1164/rccm.200210-1216OC?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
DOI
10.1164/rccm.200210-1216OC
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34912
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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