계명대학교 의학도서관 Repository

Thyroid Autoimmunity and its Association with Cellular and Humoral Immunity in Women with Reproductive Failures

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Author(s)
Na Young KimHye Jin ChoHeun Yun KimKwang Moon YangHyun Kyong AhnSimon ThorntonJoon Cheol ParkKenneth BeamanAlice Gilman-SachsJoanne Kwak-Kim
Keimyung Author(s)
Park, Joon Cheol
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
American Journal of Reproductive Immunology
Issued Date
2011
Volume
65
Issue
1
Abstract
Keywords:

Cellular immunity;
pregnancy;
reproductive failure;
thyroid autoimmunity;
thyroid function



Citation Kim NY, Cho HJ, Kim HY, Yang KM, Ahn HK, Thornton S, Park JC, Beaman K, Gilman-Sachs A, Kwak-Kim J. Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures. Am J Reprod Immunol 2011; 65: 78–87


Problem  Thyroid autoimmunity (TAI), which is T helper (Th)1-cell-mediated autoimmunity to thyrocytes, is associated with increased risk of miscarriages and highly prevalent in women with infertility. We aim at investigating the prevalence of TAI in women with recurrent spontaneous abortions (RSA) or unexplained infertility (UI) and its relationship with cellular and humoral immune abnormalities.


Method of study  Prevalence of antiphospholipid antibodies, anti-nuclear antibody, other non-organ-specific antibodies (NOSAs; anti-dsDNA, anti-ssDNA, anti-histone, anti-Scl70), peripheral blood natural killer (NK) cell levels (%) and cytotoxicity, and CD3+/CD4+ Th1/Th2 cell ratios were compared in women with and without TAI. Thyroid functional tests (TFT) were analyzed in both groups before and after pregnancy.


Results  Tumor necrosis factor-α/IL-10 expressing CD3+/CD4+ cell ratios (P < 0.05), CD56+ NK cell levels (P < 0.05), the prevalence of anticardiolipin antibodies (P < 0.05) and other NOSAs (P < 0.005) were significantly higher in women with TAI when compared to women without TAI. Changes in thyroid-stimulating hormone levels between before and after pregnancy in women with TAI were significantly higher when compared to those of women without TAI (P < 0.05).


Conclusion  TAI is associated with impaired cellular and humoral immune responses in women with RSA or UI. In women with TAI, serial TFT is recommended when pregnancy is established.
Keimyung Author(s)(Kor)
박준철
Publisher
School of Medicine
Citation
Na Young Kim et al. (2011). Thyroid Autoimmunity and its Association with Cellular and Humoral Immunity in Women with Reproductive Failures. American Journal of Reproductive Immunology, 65(1), 78–87. doi: 10.1111/j.1600-0897.2010.00911.x
Type
Article
ISSN
1046-7408
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0897.2010.00911.x
DOI
10.1111/j.1600-0897.2010.00911.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34945
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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