계명대학교 의학도서관 Repository

Upregulated Amniotic Fluid Cytokines and Chemokines in Emergency Cerclage with Protruding Membranes

Metadata Downloads
Author(s)
Joon-Cheol ParkDong-Ja KimJoanne Kwak-kim
Keimyung Author(s)
Park, Joon Cheol
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
American Journal of Reproductive Immunology
Issued Date
2011
Volume
66
Issue
4
Abstract
Keywords:

Chemokine;
C-reactive protein;
cytokine;
emergency cervical cerclage;
prognosis



Citation Park J-C, Kim D-J, Kwak-Kim J. Upregulated amniotic fluid cytokines and chemokines in emergency cerclage with protruding membranes. Am J Reprod Immunol 2011; 66: 310–319


Problem  To identify the prognostic factors for pregnancy outcome in women who received emergency cerclage for dilated cervix with protruding membranes.


Method of study  A prospective cohort study was performed, and a total of 14 women who received emergency cerclage were included. Clinical features and laboratory findings including amniotic fluid cytokines and chemokines were compared between women who had successful pregnancy (survival group, n = 6) and those who had perinatal death (non-survival group, n = 8). Five healthy pregnant women served for normal controls for amniotic fluid study.


Results  The overall neonatal survival was 42.9% in women with emergency cerclage. Serum C-reactive protein levels on postoperative day 3 and 7 were significantly higher in non-survival group when compared with those in survival group (P = 0.002, P = 0.01). Amniotic fluid levels of interleukin (IL)-1α, IL-1β, IL-6, IL-8, IL-10, tumor necrosis factor-α, and monocyte chemoattractant protein-1 levels of the patients were significantly higher than those of normal controls. Amniotic fluid levels of IL-1α, IL-1β, and IL-8 were significantly increased in the non-survival group when compared with those of the survival group.


Conclusion  Systemic and local inflammatory markers including proinflammatory cytokines and chemokines may predict pregnancy outcome in women with emergency cerclage for dilated cervix with protruding membranes.
Keimyung Author(s)(Kor)
박준철
Publisher
School of Medicine
Citation
Joon-Cheol Park et al. (2011). Upregulated Amniotic Fluid Cytokines and Chemokines in Emergency Cerclage with Protruding Membranes. American Journal of Reproductive Immunology, 66(4), 310–319. doi: 10.1111/j.1600-0897.2011.00991.x
Type
Article
ISSN
1046-7408
Source
https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0897.2011.00991.x
DOI
10.1111/j.1600-0897.2011.00991.x
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34946
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
Authorize & License
  • Authorize공개
  • EmbargoForever
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.