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Comparison of Levofloxacin versus Moxifloxacin for Multidrug-Resistant Tuberculosis

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Author(s)
Won-Jung KohSeung Heon LeeYoung Ae KangChang-Hoon LeeJae Chol ChoiJae Ho LeeSeung Hun JangKwang Ha YooKi Hwan JungKi Uk KimSang Bong ChoiYon Ju RyuKyung Chan KimSoojung UmYong Soo KwonYee Hyung KimWon-Il ChoiKyeongman JeonYong Il HwangSe Joong KimYoung Seok LeeEun Young HeoJuhee LeeYeo WoonKiTae Sun ShimJae-Joon Yim
Keimyung Author(s)
Choi, Won Il
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Journal of Respiratory and Critical Care Medicine
Issued Date
2013
Volume
188
Issue
7
Abstract
Rationale: Levofloxacin (LFX) and moxifloxacin (MXF) are the two most frequently recommended fluoroquinolones for treatment of patients with multidrug-resistant tuberculosis (MDR-TB). However, studies comparing the effectiveness of LFX and MXF among patients with MDR-TB are lacking.

Objectives: To compare the effectiveness of LFX and MXF in terms of culture conversion after 3 months of treatment for MDR-TB.

Methods: In this prospective multicenter randomized open label trial, we randomly assigned 182 patients with MDR-TB (sensitive to LFX and MXF) to receive either LFX (750 mg/day; 90 patients) or MXF (400 mg/day; 92 patients) with a background drug regimen. The primary outcome was the proportion of patients who achieved sputum culture conversion at 3 months of treatment. Secondary outcomes were time to culture conversion and time to smear conversion, with data censored at 3 months, and the proportions of adverse drug reactions.

Measurements and Main Results: At 3 months of treatment, 68 (88.3%) of the 77 patients in the LFX group and 67 (90.5%) of the 74 in the MXF group showed conversion to negative sputum cultures (odds ratio for LFX compared with MXF, 0.78; 95% confidence interval, 0.27–2.20). Adverse drug reactions were reported in six patients (7.7%) in the LFX group and four (5.2%) in the MXF group (P = 0.75).

Conclusions: The choice of LFX or MXF for treatment of patients with MDR-TB may not affect sputum culture conversion at 3 months of treatment.

Clinical trial registered with www.clinicaltrials.gov (NCT 01055145).

KEYWORDS: multidrug-resistant tuberculosis, fluoroquinolone, moxifloxacin, levofloxacin



Read More: http://www.atsjournals.org/doi/abs/10.1164/rccm.201303-0604OC#.VoxntU8axZQ
Keimyung Author(s)(Kor)
최원일
Publisher
School of Medicine
Citation
Won-Jung Koh et al. (2013). Comparison of Levofloxacin versus Moxifloxacin for Multidrug-Resistant Tuberculosis. American Journal of Respiratory and Critical Care Medicine, 188(7), 858–64. doi: 10.1164/rccm.201303-0604OC
Type
Article
ISSN
1073-449X
Source
https://www.atsjournals.org/doi/abs/10.1164/rccm.201303-0604OC?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed
DOI
10.1164/rccm.201303-0604OC
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34947
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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