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Hepatic fatty acid and cholesterol metabolism in nephrotic syndrome

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Author(s)
Seungyeup HanNosratola D VaziriPavan GollapudiVincent KwokHamid Moradi
Keimyung Author(s)
Han, Seung Yeup
Department
Dept. of Internal Medicine (내과학)
Journal Title
American Journal of Transplantation
Issued Date
2013
Volume
5
Issue
2
Abstract
Heavy proteinuria (nephrotic syndrome) is associated with hypercholesterolemia, hypertriglyceridemia and
a high risk of atherosclerosis. Hypertriglyceridemia in nephrotic syndrome (NS) is partly due to increased TG and
TG-rich lipoprotein production. However, data on the effect of NS on fatty acid production and catabolic machinery
are limited. NS was induced in male Sprague Dawley rats by IP injection of puromycin aminonucleoside. Six weeks
after the second injection the animals were euthanized, liver was harvested and processed. The NS group exhibited
heavy proteinuria, hypercholesterolemia, hypertriglyceridemia, activation of SREBP-1 and LXR α/β, up-regulation of
FAS, ACC and HMG CoA reductase. In contrast hepatic tissue ChREBP activity was reduced in NS excluding its role in
upregulation of FA synthetic pathway. Despite increased expression and nuclear translocation of PPARα, expression
of ACO and abundance of CPT and L-FABP, were decreased in the liver of nephrotic animals. Therefore, NS results in
upregulation of FA production machinery. Increased hepatic fatty acid production capacity in NS is compounded by
reduced FA catabolism, events that contribute to the associated hypertiglyceridemia.
Keywords: Atherosclerosis, dyslipidemia, proteinuria, cardiovascular disease, fatty acids
Keimyung Author(s)(Kor)
한승엽
Publisher
School of Medicine
Citation
Seungyeup Han et al. (2013). Hepatic fatty acid and cholesterol metabolism in nephrotic syndrome. American Journal of Transplantation, 5(2), 246–253.
Type
Article
ISSN
1943-8141
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34952
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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