계명대학교 의학도서관 Repository

Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes

Metadata Downloads
Author(s)
Jin Mo KimYoung Ho JangJun Kim
Keimyung Author(s)
Kim, Jin Mo
Department
Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Journal Title
Anesthesia and Pain Medicine
Issued Date
2011
Volume
61
Issue
5
Abstract
During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning (I-Pre) or ischemic postconditioning (I-Post). Both δ- and κ-opioid receptors (OPRs) play a crucial role in opioid-induced cardioprotection (OIC). Down stream signaling effectors of OIC include ATP-sensitive potassium (KATP) channels, protein kinase C (PKC), tyrosine kinase, phosphatidylinositol-3-kinase (PI3-kinase), extracellular signal regulated kinase1/2 (ERK1/2), glycogen synthase kinase-3β (GSK-3β), and mitochondrial permeability transition pore (MPTP), among others. Recently, various reports also suggest that opioids could provide cardioprotection in humans. This review will discuss OIC using mostly morphine and remifentanil which are widely used during cardiac anesthesia in addition to the clinical implications of OIC. (Korean J Anesthesiol 2011; 61: 358-366)
Key Words: Ischemic postconditioning, Ischemic preconditioning, Morphine, Myocardial ischemia, Myocardial reperfusion, Remifentanil.
Keimyung Author(s)(Kor)
김진모
Publisher
School of Medicine
Citation
Jin Mo Kim et al. (2011). Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes. Anesthesia and Pain Medicine, 61(5), 358–366. doi: 10.4097/kjae.2011.61.5.358
Type
Article
ISSN
2005-6419
DOI
10.4097/kjae.2011.61.5.358
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34963
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anesthesiology & Pain Medicine (마취통증의학)
Authorize & License
  • Authorize공개
Files in This Item:

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.