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Possible Existence of Melanocytes or Melanoblasts in Human Sebaceous Glands

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Author(s)
Yong Hyun JangSang Lim KimJin Sub LeeKun-Young KwonSeok-Jong LeeDo Won KimWeon Ju Lee
Keimyung Author(s)
Kwon, Kun Young
Department
Dept. of Pathology (병리학)
Journal Title
Annals of Dermatology
Issued Date
2014
Volume
26
Issue
4
Abstract
Background: Melanocytes are present in both basal epidermis
and hair follicles. Melanocyte stem cells have been
found in hair follicle bulge. During embryogenesis, the outer
cells of the bulge differentiate into the sebaceous gland (SG)
and proliferate. Objective: To identify and determine the
distribution and morphological characteristics of melanocytes
in human SGs. Methods: A total of 171 biopsy specimens
of face and scalp were studied. Of these specimens,
103 samples contained SGs. We conducted a retrospective
review of slides stained with H&E, F-M, anti-S100, anti-c-kit,
anti-HMB-45, anti-CD1a, anti-MITF, and anti-tyrosinase.
The presence and distribution of melanocytes in human SGs
was also evaluated by electron microscopy. In addition,
melanocytes were isolated from SGs for primary culture.
Results: S-100-positive cells were observed mainly at the
periphery of SGs in 34 of 54 specimens. We did not find
F-M-positive and HMB-45-positive cells in SGs. CD1a-positve
cells were identified in two specimens. We also found
c-kit-, MITF-, and tyrosinase-positive cells in SGs. Electron
micrograph showed the presence of melanocytes in the
suprabasal portion of SGs. These melanocytes showed fewer
melanin-containing granules than the melanocytes of basal
epidermis. However, the individually distributed melanosomes
in suprabasal melanocytes were larger than those in
epidermal melanocytes. Primary culture of melanocytes
derived from SGs showed morphologically homogeneous,
slender cell bodies with few dendrites. Conclusion: Our
study confirms the presence of non-melanogenic melanocytes
and Langerhans cells in human SGs. In addition, the
characteristics of the melanocytes in SGs were found to be
different from those of the epidermal melanocytes. (Ann
Dermatol 26(4) 469∼473, 2014)
-Keywords-
Langerhans cells, Melanocytes, Sebaceous glands
Keimyung Author(s)(Kor)
권건영
Publisher
School of Medicine
Citation
Yong Hyun Jang et al. (2014). Possible Existence of Melanocytes or Melanoblasts in Human Sebaceous Glands. Annals of Dermatology, 26(4), 469–473. doi: 10.5021/ad.2014.26.4.469
Type
Article
ISSN
1013-9087
DOI
10.5021/ad.2014.26.4.469
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34966
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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