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Correlations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms

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Author(s)
Jung-Sook HaYu-Kyung KimSoon-Il JungHe-Ra JungIn-Sung Chung
Keimyung Author(s)
Ha, Jung SookJung, Hye RaChung, In Sung
Department
Dept. of Laboratory Medicine (진단검사의학)
Dept. of Pathology (병리학)
Dept. of Preventive Medicine (예방의학)
Journal Title
Annals of Laboratory Medicine
Issued Date
2012
Volume
32
Issue
6
Keyword
Janus kinase 2AlleleMyeloproliferative neoplasm
Abstract
Background: This study evaluated potential correlations between the allele burden of the
Janus kinase 2 (JAK2) V617F mutation and clinicohematologic characteristics in patients
with myeloproliferative neoplasms (MPN).
Methods: Clinical and hematologic features were reviewed for 103 MPN patients, including
patients with polycythemia vera (PV, 22 patients), essential thrombocythemia (ET, 64
patients), and primary myelofibrosis (PMF, 17 patients). JAK2 V617F allele status and allele
burdens were measured by allele-specific PCR and pyrosequencing, respectively.
Results: The JAK2 V617F mutation was detected in 95.5%, 68.8%, and 52.9% of PV, ET,
and PMF patients, respectively. JAK2 V617F-positive ET patients were significantly older
and exhibited higher neutrophil fractions, a higher frequency of thrombotic events, and a
higher myelofibrosis rate than JAK2 V617F-negative patients (P <0.05). PV patients carried
the highest mean T allele burden (66.0%±24.9%) compared with ET (40.5%±25.2%)
and PMF patients (31.5%±37.0%) (P =0.00). No significant correlations were detected
between V617F allele burden and patient age, white blood cell count, Hb, Hct, or the
platelet count for PV, ET, or PMF patients. ET patients with organomegaly had a higher
JAK2 V617F allele burden (53.4%±23.7%) than patients without organomegaly (35.6%±
24.3%) (P =0.03).
Conclusions: The JAK2 V617F mutational status and its allele burden correlate with the
clinicohematologic phenotypes of ET patients, including older age, higher neutrophil
count, and greater rates of organomegaly, thrombotic events, and myelofibrosis. For PV
and PMF patients, larger-scale studies involving more MPN patients are needed.
Key Words: Janus kinase 2, Allele, Myeloproliferative neoplasm
Keimyung Author(s)(Kor)
하정숙
정혜라
정인성
Publisher
School of Medicine
Citation
Jung-Sook Ha et al. (2012). Correlations between Janus Kinase 2 V617F Allele Burdens and Clinicohematologic Parameters in Myeloproliferative Neoplasms. Annals of Laboratory Medicine, 32(6), 385–391. doi: 10.3343/alm.2012.32.6.385
Type
Article
ISSN
2234-3806
DOI
10.3343/alm.2012.32.6.385
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34975
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학)
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