계명대학교 의학도서관 Repository

Prediction for Recurrence Using F-18 FDG PET/CT in Pathologic N0 Lung Adenocarcinoma After Curative Surgery

Metadata Downloads
Author(s)
Do-Hoon KimSeung Hyun SonChoon-Young KimChae Moon HongJong-Ryool OhBong-Il SongHae Won KimShin Young JeongSang-Woo LeeJaetae LeeByeong-Cheol Ahn
Keimyung Author(s)
Song, Bong Il
Department
Dept. of Nuclear Medicine (핵의학)
Journal Title
Annals of Surgical Oncology
Issued Date
2014
Volume
21
Issue
2
Abstract
Background

The aim of this study was to investigate risk factors for recurrence in patients with lung adenocarcinoma (LAD) who were pathologically N0 (pN0) after curative surgical resection.


Methods

A total of 102 LAD patients (M/F = 55/47, mean age, 62.6 ± 9.4 years) diagnosed as pN0 after curative surgery were included in this study. Clinical, biochemical, radiologic, and pathologic findings were reviewed and analyzed for recurrence. Metabolic parameters [SUVmax, metabolic tumor volume (MTV), total lesion glycolysis (TLG)] on pretreatment F-18 FDG PET/CT were also obtained and analyzed for recurrence.


Results

Of 102 patients, 38 (37.3 %) were found to experience recurrence for 33.6 ± 16.3 months. SUVmax, MTV, and TLG were significantly higher in patients with recurrence. The optimal cutoff values determined using a receiver-operating characteristic curve were 6.90 for SUVmax, 10.78 cm3 for MTV, and 39.68 for TLG. Univariate analysis showed that tumor size, tumor marker, SUVmax, MTV, and TLG were prognostic factors for recurrence. In multivariate analyses, after adjusting for age, sex, tumor size, pathologic T stage, and tumor marker, high SUVmax, MTV, and TLG showed an association with an increased risk of recurrence.


Conclusions

Metabolic parameters on pretreatment F-18 FDG PET/CT can predict recurrence in pN0 LAD patients who underwent curative surgery. Therefore, patients with high metabolic parameters on PET can be considered as candidates for adjuvant therapy to reduce recurrence and should be monitored carefully for early detection of possible recurrence.
Keimyung Author(s)(Kor)
송봉일
Publisher
School of Medicine
Citation
Do-Hoon Kim et al. (2014). Prediction for Recurrence Using F-18 FDG PET/CT in Pathologic N0 Lung Adenocarcinoma After Curative Surgery. Annals of Surgical Oncology, 21(2), 589–596. doi: 10.1245/s10434-013-3270-5
Type
Article
ISSN
1068-9265
Source
https://link.springer.com/article/10.1245%2Fs10434-013-3270-5
DOI
10.1245/s10434-013-3270-5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/34984
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.