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Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders

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Author(s)
In Seuk JeungSoyoung LeeHeung Sik KimChang Ki Yeo
Keimyung Author(s)
Lee, So YoungKim, Heung SikYeo, Chang Ki
Department
Dept. of Rehabilitation Medicine (재활의학)
Dept. of Pediatrics (소아청소년학)
Dept. of Otorhinolaryngology (이비인후과학)
Journal Title
Annals of Rehabilitation Medicine
Issued Date
2012
Volume
36
Issue
3
Abstract
Objective To determine the 9 month period eff ect of botulinum toxin A (BoNT-A) injection into the salivary gland
in children with neurologic disorders and sialorrhea by qualifi ed parent/caregiver-administered questionnaires.
Method A total of 17 patients (age 7.6±4.24 years) were enrolled in this study. The degree of sialorrhea was
assessed at the baseline, 2 weeks, 1, 2, 4, 6 and 9 months after injection. Th e Drooling Count (DC) was assessed as
an objective measurement. Th e Drooling Frequency and Severity Scale (DFS) and the Teacher Drooling Scale (TDS)
were evaluated as a subjective measurement. BoNT-A (0.5 unit/kg) was injected into each submandibular and
parotid gland under ultrasonography-guidance.
Results DC, DFS and TDS showed signifi cant improvement at 2 weeks, 1, 2, 4, 6, and 9 months follow-up (p<0.05).
Twelve of 17 cases (70.5%) showed more than 50% reduction in DC from the baseline value.
Conclusion Ultrasonography-guided BoNT-A injection into the submandibular and parotid gland was a safe and
eff ective method to treat sialorrhea in children with neurologic disorders.
Key Words Sialorrhea, Botulinum toxin, Salivary gland, Children, Neurologic disorder
Keimyung Author(s)(Kor)
이소영
김흥식
여창기
Publisher
School of Medicine
Citation
In Seuk Jeung et al. (2012). Effect of Botulinum Toxin A Injection into the Salivary Glands for Sialorrhea in Children with Neurologic Disorders. Annals of Rehabilitation Medicine, 36(3), 340–346. doi: 10.5535/arm.2012.36.3.340
Type
Article
ISSN
2234-0645
DOI
10.5535/arm.2012.36.3.340
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35028
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학)
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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