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Effect of Intradiscal Methylene Blue Injection for the Chronic Discogenic Low Back Pain: One Year Prospective Follow-up Study

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Author(s)
Soo-Hyun KimSang-Ho AhnYun-Woo ChoDong-Gyu Lee
Keimyung Author(s)
Lee, Dong Gyu
Department
Dept. of Rehabilitation Medicine (재활의학)
Journal Title
Annals of Rehabilitation Medicine
Issued Date
2012
Volume
36
Issue
5
Abstract
Objective To evaluate the efficacy of intradiscal methylene blue (MB) injection in patients with chronic discogenic low back pain.Method Twenty patients with discogenic low back pain (4 males, 16 females; mean age 45.6 years) refractory to conservative management were recruited. All subjects underwent MB injection in target lumbar intervertebral discs confirmed by provocative discography. The clinical outcome was assessed by visual analog scale (VAS) and Oswestry disability index (ODI) at baseline and 1, 3, 6 and 12 months after treatment. Successful outcome was described as minimum of 2 points reduction in pain intensity compared with the baseline.Results VAS and ODI significantly decreased after one injection. The average VAS and ODI were reduced significantly from 5.1 and 38.0 at baseline to 3.2 and 27.4 at 3 months after injection (p<0.05). However, the mean score of VAS at 12 month follow-up was 4.5 and we could not observe any difference between 12 months after injection and pretreatment. Eleven of twenty patients (55%) reported successful outcomes after intradiscal MB injection at 3 month follow up and the average VAS was reduced by 3.3±1.1 (p<0.05). At the time of 12 month follow up, pain had relapsed in 6 patients who have had satisfactory effect at 3 month follow up. Successful outcome was maintained in only 5 patients (20%) for 1 year.Conclusion The intradiscal MB injection is a short-term effective minimally invasive treatment indicated for discogenic back pain but it may lose its effectiveness long-term.Key Words Intradiscal methylene blue injection, Discogenic low back pain
Keimyung Author(s)(Kor)
이동규
Publisher
School of Medicine
Citation
Soo-Hyun Kim et al. (2012). Effect of Intradiscal Methylene Blue Injection for the Chronic Discogenic Low Back Pain: One Year Prospective Follow-up Study. Annals of Rehabilitation Medicine, 36(5), 657–664. doi: 10.5535/arm.2012.36.5.657
Type
Article
ISSN
2234-0645
DOI
10.5535/arm.2012.36.5.657
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35029
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학)
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