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The Risk of Lymph Node Metastasis Based on Myometrial Invasion and Tumor Grade in Endometrioid Uterine Cancers: A Multicenter, Retrospective Korean Study

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Author(s)
Kwang-Beom LeeKyung-Do KiJong-Min LeeJae-Kwan LeeJae Weon KimChi-Heum ChoSeok-Mo KimSang-Yoon ParkDae-Hoon JeongKi-Tae Kim
Keimyung Author(s)
Cho, Chi Heum
Department
Dept. of Obstetrics & Gynecology (산부인과학)
Journal Title
Annals of Surgical Oncology
Issued Date
2009
Volume
16
Issue
10
Abstract
Background. Knowledge of the risk factors for lymph
node metastasis (LNM) is necessary to treat patients with
endometrioid uterine cancer to optimize and further individualize
treatment. This study was designed to determine
the risk of LNM based on myometrial invasion and tumor
grade in endometrioid uterine cancer.
Methods. The authors retrospectively reviewed the medical
records and pathological findings of 834 patients who
underwent surgical staging, including pelvic lymphadenectomy
with or without para-aortic lymphadenectomy, for
endometrioid uterine cancer from 2002 to 2008 in Korea.
Results. Of the 834 patients with endometrioid uterine
cancer, 107 (12.8%) patients had LNM. Sixty-one (57%)
patients had only pelvic LNM, 39 (36.4%) had pelvic and
para-aortic LNM, and 7 (6.6%) had isolated para-aortic
LNM. Tumor grade, myometrial invasion, tumor diameter,
cervical extension, lymphovascular space invasion, and
adnexal involvement were found to be significant predictors
of LNM. Of 215 patients with no myometrial invasion
and tumor grade I/II, only 1 (0.47%) had LNM. However,
in other patients, the risk of LNM was significant and at
least[3.5%. Furthermore, the risk of LNM was found to
be well correlated with increases in myometrial invasion
and tumor grade based on subgroup analyses, when
patients with no myometrial invasion and tumor grade I/II
were used as a reference group (p\0.0001).
Conclusions. Patients with endometrioid uterine cancers
with no myometrial invasion and tumor grade I/II might
have minimal risk of LNM, whereas others might require
complete pelvic and para-aortic lymphadenectomy for
surgical staging.
Keimyung Author(s)(Kor)
조치흠
Publisher
School of Medicine
Citation
Kwang-Beom Lee et al. (2009). The Risk of Lymph Node Metastasis Based on Myometrial Invasion and Tumor Grade in Endometrioid Uterine Cancers: A Multicenter, Retrospective Korean Study. Annals of Surgical Oncology, 16(10), 2882–2887. doi: 10.1245/s10434-009-0535-0
Type
Article
ISSN
1068-9265
Source
https://link.springer.com/article/10.1245%2Fs10434-009-0535-0
DOI
10.1245/s10434-009-0535-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35045
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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