계명대학교 의학도서관 Repository

Genetics and Gastrointestinal Symptoms

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Author(s)
Margaret M. HeitkemperRuth KohenSang-Eun JunMonica E. Jarrett
Keimyung Author(s)
Jun, Sang Eun
Department
Dept. of Nursing (간호학)
Journal Title
Annual Review of Nursing Research
Issued Date
2011
Volume
29
Issue
1
Abstract
Gastrointestinal (GI) symptoms including nausea, vomiting, diarrhea, constipation, abdominal discomfort/pain, and heartburn are ubiquitous and as such are often the focus of nursing interventions. The etiologies of these symptoms include GI pathology (e.g., cancer, inflammation), dietary factors (e.g., lactose intolerance), infection, stress, autonomic nervous system dysregulation, medications, as well as a host of diseases outside the GI tract. This review focuses on a common condition (irritable bowel syndrome [IBS]) that is linked with both bowel pattern and abdominal discomfort/pain symptoms. Family and twin studies give evidence for a role of genetic factors in IBS. Whether genes are directly associated with IBS or influence disease risk indirectly by modulating the response to environmental factors remains unknown at this time. Given the multifactorial nature of IBS, it is unlikely that a single genetic factor is responsible for IBS. In addition, gene–gene (epistatic) interactions are also likely to play a role. Four genes coding for proteins involved in neurotransmission (i.e., the serotonin reuptake transporter [SERT], tryptophan hydroxylase [TPH], alpha 2-adrenergic receptor [α2-ADR], catechol-o-methyl transferase [COMT]) and their potential relevance to GI symptoms and IBS will be reviewed. Further research using genome-wide association approaches with samples well characterized by ethnicity and standardized symptom subgrouping is needed.
Keimyung Author(s)(Kor)
전상은
Publisher
College of Nursing
Citation
Margaret M. Heitkemper et al. (2011). Genetics and Gastrointestinal Symptoms. Annual Review of Nursing Research, 29(1), 261–280. doi: 10.1891/0739-6686.29.261
Type
Article
ISSN
0739-6686
Source
https://search.proquest.com/docview/1015597380/CBD72F9507CD43AEPQ/13?accountid=16340
DOI
10.1891/0739-6686.29.261
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35049
Appears in Collections:
2. College of Nursing (간호대학) > Dept. of Nursing (간호학)
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