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Aquaporin 3 expression predicts survival in patients with HER2-positive early breast cancer

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Author(s)
SUNHEE KANGYEE SOO CHAESOO JUNG LEEBYUNG WOOG KANGJONG GWANG KIMWAN WOOK KIMJIN HYANG JUNGHO YONG PARKJAE-HWAN JEONGJI YUN JEONGJI-YOUNG PARK
Keimyung Author(s)
Kang, Sun Hee
Department
Dept. of Surgery (외과학)
Journal Title
Anticancer Research
Issued Date
2015
Volume
35
Issue
5
Abstract
Background/Aim: Recent studies have revealed aquaporins (AQPs) as targets for novel anti-tumor therapy since they are likely to play a role in carcinogenesis, tumor progression and invasion. Accordingly, we analyzed the prognostic impact of AQP3 expression and polymorphisms in a number of patients with early breast cancer (EBC). Materials and Methods: AQP3 expression was investigated on the basis of the immunohistochemistry of tissue microarray specimens from 447 EBC patients who underwent surgery between 2003 and 2008. We scored the staining intensity (0 through 3) and percentage of positive tumor cells (0 through 4); the staining score was defined as sum of these scores used to categorize the AQP3 expression as negative (0 through 2), weak (3 through 5) or strong (6 or more). For AQP3 polymorphisms, seven single nucleotide polymorphisms (SNPs) (rs10813981, rs34391490, rs2228332, rs2227285, rs591810, rs17553719 and rs3860987) were selected using in silico analysis and genotyped using the Sequenom MassARRAY. Results: A total of 180 (40.3%) patients were identified as AQP3-positive (staining score >2), including 86 (19.2%) cases of strong expression (stating score >5). In a univariate analysis, AQP3 expression was significantly associated with survival for the patients with HER2-over-expressing EBC. Moreover, a multivariate survival analysis revealed that AQP3 expression was an independent prognostic marker of disease-free survival (DFS): hazard ratio (HR)=3.137, 95% confidence interval (CI)=1.079-9.125, p=0.036; distant DFS (DDFS): HR=2.784, 95%CI=0.921-8.414, p=0.070, for the HER2-over-expressing EBC patients. Meanwhile, none of selected AQP3 polymorphisms were related to AQP3 expression in tumor tissue or survival in the current study. Conclusion: AQP3 expression in tumor tissue may be considered as a potential prognostic marker in patients with HER2-over-expressing EBC after curative surgery.
Keimyung Author(s)(Kor)
강선희
Publisher
School of Medicine
Citation
SUNHEE KANG et al. (2015). Aquaporin 3 expression predicts survival in patients with HER2-positive early breast cancer. Anticancer Research, 35(5), 2775–2782.
Type
Article
ISSN
0250-7005
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/35058
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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