Is Mitochondrial DNA Copy Number Associated with Clinical Characteristics and Prognosis in Gastric Cancer?
- Affiliated Author(s)
- 이현수; 이재호; 최인장; 황일선; 강유나; 김신
- Alternative Author(s)
- Lee, Hyun Su; Lee, Jae Ho; Choi, In Jang; Hwang, Il Seon; Kang, Yu Na; Kim, Shin
- Journal Title
- Asian Pacific Journal of Cancer Prevention
- Issued Date
- Alterations in mitochondrial DNA (mtDNA) have been studied in various cancers. However, the clinical
value of mtDNA copy number (mtCN) alterations in gastric cancer (GC) is poorly understood. In the present
study, we investigated whether alterations in mtCNs might be associated with clinicopathological parameters
in GC cases. mtCN was measured in 109 patients with GC by quantitative real-time PCR. Then, correlations
with clinicopathological characteristics were analyzed. mtCN was elevated in 64.2% of GC tissues compared
with paired, adjacent, non-cancerous tissue. However, the observed alterations in mtCN were not associated
with any clinicopathological characteristics, including age, gender, TN stage, Lauren classification, lymph
node metastasis, and depth of invasion. Moreover, Kaplan-Meier survival curves revealed that mtCN was not
significantly associated with the survival of GC patients. In this study, we demonstrated that mtCN was not a
significant marker for predicting clinical characteristics or prognosis in GC.
Keywords: Gastric cancer - mitochondrial DNA - copy number - prognosis
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